Enteral intake of non-metabolic monosacharide and disaccharide, followed by measurement of the urinary excretion ratio of the two, is a method used to investigate intestinal permeability. L/R ratio (lactulose/1-rhamnose urinary excretion ratio) is considered an indicator of permeability of the small intestine. An increased L/R ratio is caused by mucosal disorders of the small intestine. The L/R ratio in all patients (n = 92) with Crohn' s disease was 0.079 ± 0.081 (mean ± S D.), which was significantly higher than the value in normal controls (0.027 ± 0.009, n = 20. p<0.05). In 39 patients with Crohn's disease, we assessed intestinal permeability before after treatment with an elemental diet, and during remission. The L/R ratio was 0.120 ± 0.092. before treatment and 0.065 ± 0.097 after treatment (p<0.05), showing increased intestinal permeability before elemental dietary treatment. During remission, the L/R ratio was 0.035 ± 0.028; this did not differ significantly from the value obtained after treatment. We conclude that intestinal permeability is useful for investigating disease activity in patients with Crohn's disease.
|Number of pages||8|
|Journal||Japanese Journal of Gastroenterology|
|Publication status||Published - 2001|
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