Intestinal permeability in Crohn's disease and effects of elemental dietary therapy

M. Iwata, H. Nakano, Y. Matsuura, M. Nagasaka, M. Misawa, S. Mizuta, I. Ito, T. Saito, T. Ito, M. Hokama, M. Kamiya, R. Hobara, M. Watanabe, K. Takahama

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Enteral intake of non-metabolic monosacharide and disaccharide, followed by measurement of the urinary excretion ratio of the two, is a method used to investigate intestinal permeability. L/R ratio (lactulose/1-rhamnose urinary excretion ratio) is considered an indicator of permeability of the small intestine. An increased L/R ratio is caused by mucosal disorders of the small intestine. The L/R ratio in all patients (n = 92) with Crohn' s disease was 0.079 ± 0.081 (mean ± S D.), which was significantly higher than the value in normal controls (0.027 ± 0.009, n = 20. p<0.05). In 39 patients with Crohn's disease, we assessed intestinal permeability before after treatment with an elemental diet, and during remission. The L/R ratio was 0.120 ± 0.092. before treatment and 0.065 ± 0.097 after treatment (p<0.05), showing increased intestinal permeability before elemental dietary treatment. During remission, the L/R ratio was 0.035 ± 0.028; this did not differ significantly from the value obtained after treatment. We conclude that intestinal permeability is useful for investigating disease activity in patients with Crohn's disease.

Original languageEnglish
Pages (from-to)636-643
Number of pages8
JournalJapanese Journal of Gastroenterology
Issue number6
Publication statusPublished - 07-07-2001

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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    Iwata, M., Nakano, H., Matsuura, Y., Nagasaka, M., Misawa, M., Mizuta, S., Ito, I., Saito, T., Ito, T., Hokama, M., Kamiya, M., Hobara, R., Watanabe, M., & Takahama, K. (2001). Intestinal permeability in Crohn's disease and effects of elemental dietary therapy. Japanese Journal of Gastroenterology, 98(6), 636-643.