Intra-amniotic infection increases amniotic lamellar body count before 34 weeks of gestation

Hiroyuki Tsuda, Yuichiro Takahashi, Shigenori Iwagaki, Ichiro Kawabata, Hiromi Hayakawa, Tomomi Kotani, Kiyosumi Shibata, Fumitaka Kikkawa

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Objective.To examine the lamellar body count (LBC) value in intra-amniotic infection cases and evaluate its association with the incidence of respiratory distress syndrome (RDS). Methods.Three hundred sixty-five amniotic fluid (AF) samples were obtained at caesarean section from 27 to 38 weeks of gestation. LBC and glucose concentrations in AF were measured with no centrifugation. We defined AF glucose concentrations<0.8mmol/L and positive C-reactive protein (CRP) of the neonates as intra-amniotic infection. Results.An LBC cutoff value of 29,500/μL resulted in 94.0 sensitivity, 82.4 specificity, and 99.1 negative predictive value (NPV) for RDS. Neonates with glucose concentrations<0.8mmol/L in AF and positive CRP had no RDS and significantly higher LBC values than controls before 34 weeks of gestation (17.0 vs. 4.3, p<0.05 and 25.5 vs. 5.0, p<0.05, respectively), but there were no significant differences after 34 weeks of gestation. Conclusions.LBC is an accurate predictor of foetal lung maturity and our LBC cutoff value had a high NPV for predicting RDS. We showed that intra-amniotic infection was associated with significantly higher LBC values than the value in controls before 34 weeks of gestation, which correlated with a low incidence of RDS.

Original languageEnglish
Pages (from-to)1230-1236
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number10
Publication statusPublished - 10-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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