Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2

Hitoshi Nishimura, Toshiki Yajima, Yoshiko Kagimoto, Mutsuhiro Ohata, Taketo Watase, Kenji Kishihara, Fumi Goshima, Yukihiro Nishiyama, Yasunobu Yoshikai

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Mice depleted of γδ T cells by in vivo administration of anti-TCRγδ monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the γδ T-cell-depleted mice. Mice deficient in the Vδ1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial γδ T cells bearing Vδ1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response.

Original languageEnglish
Pages (from-to)4927-4930
Number of pages4
JournalJournal of Virology
Volume78
Issue number9
DOIs
Publication statusPublished - 05-2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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