Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2

Hitoshi Nishimura; Toshiki Yajima; Yoshiko Kagimoto; Mutsuhiro Ohata; Taketo Watase; Kenji Kishihara; Fumi Goshima; Yukihiro Nishiyama; Yasunobu Yoshikai

doi:10.1128/JVI.78.9.4927-4930.2004

Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2

Hitoshi Nishimura, Toshiki Yajima, Yoshiko Kagimoto, Mutsuhiro Ohata, Taketo Watase, Kenji Kishihara, Fumi Goshima, Yukihiro Nishiyama, Yasunobu Yoshikai

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Mice depleted of γδ T cells by in vivo administration of anti-TCRγδ monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the γδ T-cell-depleted mice. Mice deficient in the Vδ1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial γδ T cells bearing Vδ1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response.

Original language	English
Pages (from-to)	4927-4930
Number of pages	4
Journal	Journal of Virology
Volume	78
Issue number	9
DOIs	https://doi.org/10.1128/JVI.78.9.4927-4930.2004
Publication status	Published - 05-2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.78.9.4927-4930.2004

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title = "Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2",

abstract = "Mice depleted of γδ T cells by in vivo administration of anti-TCRγδ monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the γδ T-cell-depleted mice. Mice deficient in the Vδ1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial γδ T cells bearing Vδ1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response.",

author = "Hitoshi Nishimura and Toshiki Yajima and Yoshiko Kagimoto and Mutsuhiro Ohata and Taketo Watase and Kenji Kishihara and Fumi Goshima and Yukihiro Nishiyama and Yasunobu Yoshikai",

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T1 - Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2

AU - Nishimura, Hitoshi

AU - Yajima, Toshiki

AU - Kagimoto, Yoshiko

AU - Ohata, Mutsuhiro

AU - Watase, Taketo

AU - Kishihara, Kenji

AU - Goshima, Fumi

AU - Nishiyama, Yukihiro

AU - Yoshikai, Yasunobu

PY - 2004/5

Y1 - 2004/5

N2 - Mice depleted of γδ T cells by in vivo administration of anti-TCRγδ monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the γδ T-cell-depleted mice. Mice deficient in the Vδ1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial γδ T cells bearing Vδ1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response.

AB - Mice depleted of γδ T cells by in vivo administration of anti-TCRγδ monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the γδ T-cell-depleted mice. Mice deficient in the Vδ1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial γδ T cells bearing Vδ1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response.

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Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2

Abstract

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