Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals

Shinji Kawaguchi; Yusuke Soma; Kazuaki Nakajima; Hideaki Kanazawa; Shugo Tohyama; Ryota Tabei; Akinori Hirano; Noriko Handa; Yoshitake Yamada; Shigeo Okuda; Shuji Hishikawa; Takumi Teratani; Satoshi Kunita; Yoshikazu Kishino; Marina Okada; Sho Tanosaki; Shota Someya; Yuika Morita; Hidenori Tani; Yujiro Kawai; Masataka Yamazaki; Akira Ito; Rei Shibata; Toyoaki Murohara; Yasuhiko Tabata; Eiji Kobayashi; Hideyuki Shimizu; Keiichi Fukuda; Jun Fujita

doi:10.1016/j.jacbts.2020.11.017

Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals

Shinji Kawaguchi, Yusuke Soma, Kazuaki Nakajima, Hideaki Kanazawa, Shugo Tohyama, Ryota Tabei, Akinori Hirano, Noriko Handa, Yoshitake Yamada, Shigeo Okuda, Shuji Hishikawa, Takumi Teratani, Satoshi Kunita, Yoshikazu Kishino, Marina Okada, Sho Tanosaki, Shota Someya, Yuika Morita, Hidenori Tani, Yujiro KawaiMasataka Yamazaki, Akira Ito, Rei Shibata, Toyoaki Murohara, Yasuhiko Tabata, Eiji Kobayashi, Hideyuki Shimizu, Keiichi Fukuda, Jun Fujita

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study.

Original language	English
Pages (from-to)	239-254
Number of pages	16
Journal	JACC: Basic to Translational Science
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/j.jacbts.2020.11.017
Publication status	Published - 03-2021
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2020.11.017

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Kawaguchi, S., Soma, Y., Nakajima, K., Kanazawa, H., Tohyama, S., Tabei, R., Hirano, A., Handa, N., Yamada, Y., Okuda, S., Hishikawa, S., Teratani, T., Kunita, S., Kishino, Y., Okada, M., Tanosaki, S., Someya, S., Morita, Y., Tani, H., ... Fujita, J. (2021). Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals. JACC: Basic to Translational Science, 6(3), 239-254. https://doi.org/10.1016/j.jacbts.2020.11.017

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title = "Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals",

abstract = "The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study.",

author = "Shinji Kawaguchi and Yusuke Soma and Kazuaki Nakajima and Hideaki Kanazawa and Shugo Tohyama and Ryota Tabei and Akinori Hirano and Noriko Handa and Yoshitake Yamada and Shigeo Okuda and Shuji Hishikawa and Takumi Teratani and Satoshi Kunita and Yoshikazu Kishino and Marina Okada and Sho Tanosaki and Shota Someya and Yuika Morita and Hidenori Tani and Yujiro Kawai and Masataka Yamazaki and Akira Ito and Rei Shibata and Toyoaki Murohara and Yasuhiko Tabata and Eiji Kobayashi and Hideyuki Shimizu and Keiichi Fukuda and Jun Fujita",

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doi = "10.1016/j.jacbts.2020.11.017",

language = "English",

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Kawaguchi, S, Soma, Y, Nakajima, K, Kanazawa, H, Tohyama, S, Tabei, R, Hirano, A, Handa, N, Yamada, Y, Okuda, S, Hishikawa, S, Teratani, T, Kunita, S, Kishino, Y, Okada, M, Tanosaki, S, Someya, S, Morita, Y, Tani, H, Kawai, Y, Yamazaki, M, Ito, A, Shibata, R, Murohara, T, Tabata, Y, Kobayashi, E, Shimizu, H, Fukuda, K & Fujita, J 2021, 'Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals', JACC: Basic to Translational Science, vol. 6, no. 3, pp. 239-254. https://doi.org/10.1016/j.jacbts.2020.11.017

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AU - Soma, Yusuke

AU - Nakajima, Kazuaki

AU - Kanazawa, Hideaki

AU - Tohyama, Shugo

AU - Tabei, Ryota

AU - Hirano, Akinori

AU - Handa, Noriko

AU - Yamada, Yoshitake

AU - Okuda, Shigeo

AU - Hishikawa, Shuji

AU - Teratani, Takumi

AU - Kunita, Satoshi

AU - Kishino, Yoshikazu

AU - Okada, Marina

AU - Tanosaki, Sho

AU - Someya, Shota

AU - Morita, Yuika

AU - Tani, Hidenori

AU - Kawai, Yujiro

AU - Yamazaki, Masataka

AU - Ito, Akira

AU - Shibata, Rei

AU - Murohara, Toyoaki

AU - Tabata, Yasuhiko

AU - Kobayashi, Eiji

AU - Shimizu, Hideyuki

AU - Fukuda, Keiichi

AU - Fujita, Jun

PY - 2021/3

Y1 - 2021/3

N2 - The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study.

AB - The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study.

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Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals

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