Invasion by human herpesvirus 6 and human herpesvirus 7 of the central nervous system in patients with neurological signs and symptoms

T. Yoshikawa, M. Ihira, K. Suzuki, S. Suga, T. Matsubara, S. Furukawa, Y. Asano

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Methods - A total of 43 children with neurological signs and symptoms were enrolled in the study. All children were suspected of having meningitis, and lumbar punctures were performed. Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction. Results - Most patients had detectable serum antibody to both HHV6 and 7. HHV6 DNA was detected in PBMC of 15 patients and in CSF cell pellet of seven. Corresponding figures for HHV7 were 28 and 6.2/7, and 5/6 with CSF viral DNA also had it in PBMC, respectively. No viral DNA was detected in CSF supernatants. The seven HHV6 CSF viruses were all variant B. Conclusion - These data suggest that HHV-7 may invade the CNS.

Original languageEnglish
Pages (from-to)170-171
Number of pages2
JournalArchives of Disease in Childhood
Volume83
Issue number2
DOIs
Publication statusPublished - 14-09-2000

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Human Herpesvirus 7
Human Herpesvirus 6
Signs and Symptoms
Cerebrospinal Fluid
Central Nervous System
Blood Cells
Viral DNA
Spinal Puncture
DNA
Meningitis
Viruses
Polymerase Chain Reaction
Antibodies
Serum

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "Methods - A total of 43 children with neurological signs and symptoms were enrolled in the study. All children were suspected of having meningitis, and lumbar punctures were performed. Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction. Results - Most patients had detectable serum antibody to both HHV6 and 7. HHV6 DNA was detected in PBMC of 15 patients and in CSF cell pellet of seven. Corresponding figures for HHV7 were 28 and 6.2/7, and 5/6 with CSF viral DNA also had it in PBMC, respectively. No viral DNA was detected in CSF supernatants. The seven HHV6 CSF viruses were all variant B. Conclusion - These data suggest that HHV-7 may invade the CNS.",
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Invasion by human herpesvirus 6 and human herpesvirus 7 of the central nervous system in patients with neurological signs and symptoms. / Yoshikawa, T.; Ihira, M.; Suzuki, K.; Suga, S.; Matsubara, T.; Furukawa, S.; Asano, Y.

In: Archives of Disease in Childhood, Vol. 83, No. 2, 14.09.2000, p. 170-171.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Invasion by human herpesvirus 6 and human herpesvirus 7 of the central nervous system in patients with neurological signs and symptoms

AU - Yoshikawa, T.

AU - Ihira, M.

AU - Suzuki, K.

AU - Suga, S.

AU - Matsubara, T.

AU - Furukawa, S.

AU - Asano, Y.

PY - 2000/9/14

Y1 - 2000/9/14

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AB - Methods - A total of 43 children with neurological signs and symptoms were enrolled in the study. All children were suspected of having meningitis, and lumbar punctures were performed. Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction. Results - Most patients had detectable serum antibody to both HHV6 and 7. HHV6 DNA was detected in PBMC of 15 patients and in CSF cell pellet of seven. Corresponding figures for HHV7 were 28 and 6.2/7, and 5/6 with CSF viral DNA also had it in PBMC, respectively. No viral DNA was detected in CSF supernatants. The seven HHV6 CSF viruses were all variant B. Conclusion - These data suggest that HHV-7 may invade the CNS.

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