Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men

Kunihiro Matsushita, Hiroshi Yatsuya, Koji Tamakoshi, Keiko Wada, Rei Otsuka, Huiming Zhang, Kaichiro Sugiura, Takahisa Kondo, Toyoaki Murohara, Hideaki Toyoshima

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective: An inverse association between adiponectin and C-reactive protein (CRP) has been shown in certain pathological states including obesity, diabetes, and coronary artery disease, which themselves might have confounded this association. This study investigated the association between adiponectin and CRP among substantially healthy subjects. Methods and results: A population of 2347 middle-aged Japanese men with no medical history of cardiovascular disease, cancer, diabetes, hypertension, or hyperlipidemia was evaluated. Those with some metabolic syndrome components from serological and anthropometric tests were excluded, leaving 714 men for analysis. Serum adiponectin and CRP were significantly correlated (r = -0.21, P < 0.001). After categorization into quartiles from the lowest to the highest adiponectin concentration (Q1 to Q4), the CRP level was found to be significantly higher in Q1 than in Q2, Q3 and Q4 (0.41 mg/L versus 0.30, 0.25 and 0.24 mg/L, P = 0.043, P < 0.001 and P < 0.001, respectively). These associations remained significant even after adjustment for covariates. Moreover, multiple linear regression analysis revealed that adiponectin contributed more strongly to CRP than other factors, including the index of insulin resistance. Conclusions: An inverse and strong association between adiponectin and CRP in substantially healthy subjects implies that decreased serum adiponectin might be fundamentally associated with the early stage of low-grade inflammation.

Original languageEnglish
Pages (from-to)184-189
Number of pages6
JournalAtherosclerosis
Volume188
Issue number1
DOIs
Publication statusPublished - 01-09-2006
Externally publishedYes

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Adiponectin
C-Reactive Protein
Healthy Volunteers
Serologic Tests
Hyperlipidemias
Serum
Insulin Resistance
Coronary Artery Disease
Linear Models
Cardiovascular Diseases
Obesity
Regression Analysis
Hypertension
Inflammation
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Matsushita, Kunihiro ; Yatsuya, Hiroshi ; Tamakoshi, Koji ; Wada, Keiko ; Otsuka, Rei ; Zhang, Huiming ; Sugiura, Kaichiro ; Kondo, Takahisa ; Murohara, Toyoaki ; Toyoshima, Hideaki. / Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. In: Atherosclerosis. 2006 ; Vol. 188, No. 1. pp. 184-189.
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abstract = "Objective: An inverse association between adiponectin and C-reactive protein (CRP) has been shown in certain pathological states including obesity, diabetes, and coronary artery disease, which themselves might have confounded this association. This study investigated the association between adiponectin and CRP among substantially healthy subjects. Methods and results: A population of 2347 middle-aged Japanese men with no medical history of cardiovascular disease, cancer, diabetes, hypertension, or hyperlipidemia was evaluated. Those with some metabolic syndrome components from serological and anthropometric tests were excluded, leaving 714 men for analysis. Serum adiponectin and CRP were significantly correlated (r = -0.21, P < 0.001). After categorization into quartiles from the lowest to the highest adiponectin concentration (Q1 to Q4), the CRP level was found to be significantly higher in Q1 than in Q2, Q3 and Q4 (0.41 mg/L versus 0.30, 0.25 and 0.24 mg/L, P = 0.043, P < 0.001 and P < 0.001, respectively). These associations remained significant even after adjustment for covariates. Moreover, multiple linear regression analysis revealed that adiponectin contributed more strongly to CRP than other factors, including the index of insulin resistance. Conclusions: An inverse and strong association between adiponectin and CRP in substantially healthy subjects implies that decreased serum adiponectin might be fundamentally associated with the early stage of low-grade inflammation.",
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Matsushita, K, Yatsuya, H, Tamakoshi, K, Wada, K, Otsuka, R, Zhang, H, Sugiura, K, Kondo, T, Murohara, T & Toyoshima, H 2006, 'Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men', Atherosclerosis, vol. 188, no. 1, pp. 184-189. https://doi.org/10.1016/j.atherosclerosis.2005.10.031

Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. / Matsushita, Kunihiro; Yatsuya, Hiroshi; Tamakoshi, Koji; Wada, Keiko; Otsuka, Rei; Zhang, Huiming; Sugiura, Kaichiro; Kondo, Takahisa; Murohara, Toyoaki; Toyoshima, Hideaki.

In: Atherosclerosis, Vol. 188, No. 1, 01.09.2006, p. 184-189.

Research output: Contribution to journalArticle

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AU - Matsushita, Kunihiro

AU - Yatsuya, Hiroshi

AU - Tamakoshi, Koji

AU - Wada, Keiko

AU - Otsuka, Rei

AU - Zhang, Huiming

AU - Sugiura, Kaichiro

AU - Kondo, Takahisa

AU - Murohara, Toyoaki

AU - Toyoshima, Hideaki

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N2 - Objective: An inverse association between adiponectin and C-reactive protein (CRP) has been shown in certain pathological states including obesity, diabetes, and coronary artery disease, which themselves might have confounded this association. This study investigated the association between adiponectin and CRP among substantially healthy subjects. Methods and results: A population of 2347 middle-aged Japanese men with no medical history of cardiovascular disease, cancer, diabetes, hypertension, or hyperlipidemia was evaluated. Those with some metabolic syndrome components from serological and anthropometric tests were excluded, leaving 714 men for analysis. Serum adiponectin and CRP were significantly correlated (r = -0.21, P < 0.001). After categorization into quartiles from the lowest to the highest adiponectin concentration (Q1 to Q4), the CRP level was found to be significantly higher in Q1 than in Q2, Q3 and Q4 (0.41 mg/L versus 0.30, 0.25 and 0.24 mg/L, P = 0.043, P < 0.001 and P < 0.001, respectively). These associations remained significant even after adjustment for covariates. Moreover, multiple linear regression analysis revealed that adiponectin contributed more strongly to CRP than other factors, including the index of insulin resistance. Conclusions: An inverse and strong association between adiponectin and CRP in substantially healthy subjects implies that decreased serum adiponectin might be fundamentally associated with the early stage of low-grade inflammation.

AB - Objective: An inverse association between adiponectin and C-reactive protein (CRP) has been shown in certain pathological states including obesity, diabetes, and coronary artery disease, which themselves might have confounded this association. This study investigated the association between adiponectin and CRP among substantially healthy subjects. Methods and results: A population of 2347 middle-aged Japanese men with no medical history of cardiovascular disease, cancer, diabetes, hypertension, or hyperlipidemia was evaluated. Those with some metabolic syndrome components from serological and anthropometric tests were excluded, leaving 714 men for analysis. Serum adiponectin and CRP were significantly correlated (r = -0.21, P < 0.001). After categorization into quartiles from the lowest to the highest adiponectin concentration (Q1 to Q4), the CRP level was found to be significantly higher in Q1 than in Q2, Q3 and Q4 (0.41 mg/L versus 0.30, 0.25 and 0.24 mg/L, P = 0.043, P < 0.001 and P < 0.001, respectively). These associations remained significant even after adjustment for covariates. Moreover, multiple linear regression analysis revealed that adiponectin contributed more strongly to CRP than other factors, including the index of insulin resistance. Conclusions: An inverse and strong association between adiponectin and CRP in substantially healthy subjects implies that decreased serum adiponectin might be fundamentally associated with the early stage of low-grade inflammation.

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