Inverse association between toothbrushing and upper aerodigestive tract cancer risk in a Japanese population

Fumihito Sato, Isao Oze, Daisuke Kawakita, Noriyuki Yamamoto, Hidemi Ito, Satoyo Hosono, Takeshi Suzuki, Takakazu Kawase, Hiroki Furue, Miki Watanabe, Shunzo Hatooka, Yasushi Yatabe, Yasuhisa Hasegawa, Masayuki Shinoda, Minoru Ueda, Kazuo Tajima, Hideo Tanaka, Keitaro Matsuo

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41 Citations (Scopus)


Background Oral hygiene is attracting increasing attention as a potential risk factor for cancers. To investigate the association between toothbrushing frequency and upper aerodigestive tract (UADT) cancer, the authors conducted a large-scale case-control study. Methods A total of 856 UADT cancer case participants and 2696 age- and sex-matched control subjects without cancer were included. Edentulous or participants with unknown frequency of toothbrushing or number of remaining teeth were excluded. Associations were assessed by odds ratios and 95% confidence intervals in logistic regression models with adjustment for potential confounders. Results Compared with toothbrushing once per day, the adjusted odds ratio for brushing twice or more was 0.82 (95% confidence interval: 0.68, 0.99) whereas that for not brushing was 1.79 (0.79, 4.05). This association was observed especially in subjects who had a history of heavy smoking or drinking. Conclusions The authors suggest that toothbrushing could have a protective effect for UADT cancer.

Original languageEnglish
Pages (from-to)1628-1637
Number of pages10
JournalHead and Neck
Issue number11
Publication statusPublished - 11-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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