Inverse association of serum carotenoids with prevalence of metabolic syndrome among Japanese

Koji Suzuki, Yoshinori Ito, Takashi Inoue, Nobuyuki Hamajima

Research output: Contribution to journalArticle

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Abstract

Background & aims: Several epidemiological studies have shown that circulating antioxidant levels are inversely associated with metabolic syndrome status. The purpose of this study was to examine the association of serum carotenoid levels, which have potent antioxidant effects, with metabolic syndrome and metabolic syndrome components in Japanese subjects. Methods: We conducted a cross-sectional study of 931 subjects (318 men and 613 women), aged 39-70 years, who attended a health examination. Metabolic syndrome was defined according to the diagnostic definition from the Japanese Examination Committee of Criteria for Metabolic Syndrome, which was released in 2005. Serum carotenoids were measured by high-performance liquid chromatography. Results: A significantly lower odds ratio (OR) for metabolic syndrome was observed in the highest tertile of serum β-cryptoxanthin (OR:0.45; 95% CI:0.22-0.93 in men and 0.41; 0.17-0.93 in women) and β-carotene (OR:0.45; 95% CI:0.21-0.95 in men and 0.37; 0.15-0.83 in women) compared to the lowest tertiles, in both sexes, but no significant association was found in male smokers. In women, moreover, OR for metabolic syndrome in the highest tertile of serum zeaxanthin/lutein (OR:0.37; 95% CI:0.16-0.84) was significantly lower than in the lowest tertile. Serum levels of β-cryptoxanthin, α-carotene, and β-carotene were significantly decreased with an increasing number of metabolic syndrome components in both sexes. Conclusions: These findings indicate that carotenoids may be important factors in the prevention of metabolic syndrome in nonsmokers, but further studies are required in smokers.

Original languageEnglish
Pages (from-to)369-375
Number of pages7
JournalClinical Nutrition
Volume30
Issue number3
DOIs
Publication statusPublished - 01-06-2011

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Carotenoids
Serum
Odds Ratio
Antioxidants
Lutein
Epidemiologic Studies
Cross-Sectional Studies
High Pressure Liquid Chromatography
Health

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

Cite this

Suzuki, Koji ; Ito, Yoshinori ; Inoue, Takashi ; Hamajima, Nobuyuki. / Inverse association of serum carotenoids with prevalence of metabolic syndrome among Japanese. In: Clinical Nutrition. 2011 ; Vol. 30, No. 3. pp. 369-375.
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abstract = "Background & aims: Several epidemiological studies have shown that circulating antioxidant levels are inversely associated with metabolic syndrome status. The purpose of this study was to examine the association of serum carotenoid levels, which have potent antioxidant effects, with metabolic syndrome and metabolic syndrome components in Japanese subjects. Methods: We conducted a cross-sectional study of 931 subjects (318 men and 613 women), aged 39-70 years, who attended a health examination. Metabolic syndrome was defined according to the diagnostic definition from the Japanese Examination Committee of Criteria for Metabolic Syndrome, which was released in 2005. Serum carotenoids were measured by high-performance liquid chromatography. Results: A significantly lower odds ratio (OR) for metabolic syndrome was observed in the highest tertile of serum β-cryptoxanthin (OR:0.45; 95{\%} CI:0.22-0.93 in men and 0.41; 0.17-0.93 in women) and β-carotene (OR:0.45; 95{\%} CI:0.21-0.95 in men and 0.37; 0.15-0.83 in women) compared to the lowest tertiles, in both sexes, but no significant association was found in male smokers. In women, moreover, OR for metabolic syndrome in the highest tertile of serum zeaxanthin/lutein (OR:0.37; 95{\%} CI:0.16-0.84) was significantly lower than in the lowest tertile. Serum levels of β-cryptoxanthin, α-carotene, and β-carotene were significantly decreased with an increasing number of metabolic syndrome components in both sexes. Conclusions: These findings indicate that carotenoids may be important factors in the prevention of metabolic syndrome in nonsmokers, but further studies are required in smokers.",
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Inverse association of serum carotenoids with prevalence of metabolic syndrome among Japanese. / Suzuki, Koji; Ito, Yoshinori; Inoue, Takashi; Hamajima, Nobuyuki.

In: Clinical Nutrition, Vol. 30, No. 3, 01.06.2011, p. 369-375.

Research output: Contribution to journalArticle

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