TY - JOUR
T1 - Investigation of morphological and functional changes in the small intestine with pancreatic disease
AU - Nakamura, Yosuke
AU - Itoh, Akihiro
AU - Kawashima, Hiroki
AU - Ohno, Eizaburo
AU - Itoh, Yuya
AU - Hiramatsu, Takeshi
AU - Sugimoto, Hiroyuki
AU - Sumi, Hajime
AU - Hayashi, Daijuro
AU - Kuwahara, Takamichi
AU - Funasaka, Kohei
AU - Nakamura, Masanao
AU - Miyahara, Ryoji
AU - Ohmiya, Naoki
AU - Katano, Yoshiaki
AU - Ishigami, Masatoshi
AU - Shimoyama, Yoshie
AU - Nakamura, Shigeo
AU - Goto, Hidemi
AU - Hirooka, Yoshiki
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Objectives: The aim of this study was to investigate the relationship between pancreas and small intestine evaluating the endoscopic and histopathologic findings of the proximal small intestine in pancreatic diseases. Methods: Fifty patients (18 patientswith chronic pancreatitis, 17 patients with pancreatic cancer, 15 control subjects) underwent enteroscopy using a prototype enteroscope. The villous height of the jejunum on bioptic specimens was measured, and the mean values of the villi were compared among the 3 groups. Exocrine function was calculated by the pancreatic function diagnostic test, and the correlation between the recovery rate of p-aminobenzoic acid and the villous height was assessed. Finally, the distribution of the K cells secreting glucose-dependent insulinotropic polypeptide and the L cells secreting glucagon-like peptide 1 in the duodenum and jejunum was investigated using immunohistochemistry for glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1. Results: The mean villous height in chronic pancreatitis (328 ± 67 μm) was significantly lower than that in pancreatic cancer (413 ± 57 μm) and control subjects (461 ± 97 μm) (P = 0.004 and P < 0.0001, respectively). A positive correlation was found between the recovery rate of p-aminobenzoic acid and the villous height (r = 0.52, P = 0.0001). The presence of K and L cells was verified in the duodenum and the jejunum. Conclusions: Close relationship between pancreas and small intestine was demonstrated.
AB - Objectives: The aim of this study was to investigate the relationship between pancreas and small intestine evaluating the endoscopic and histopathologic findings of the proximal small intestine in pancreatic diseases. Methods: Fifty patients (18 patientswith chronic pancreatitis, 17 patients with pancreatic cancer, 15 control subjects) underwent enteroscopy using a prototype enteroscope. The villous height of the jejunum on bioptic specimens was measured, and the mean values of the villi were compared among the 3 groups. Exocrine function was calculated by the pancreatic function diagnostic test, and the correlation between the recovery rate of p-aminobenzoic acid and the villous height was assessed. Finally, the distribution of the K cells secreting glucose-dependent insulinotropic polypeptide and the L cells secreting glucagon-like peptide 1 in the duodenum and jejunum was investigated using immunohistochemistry for glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1. Results: The mean villous height in chronic pancreatitis (328 ± 67 μm) was significantly lower than that in pancreatic cancer (413 ± 57 μm) and control subjects (461 ± 97 μm) (P = 0.004 and P < 0.0001, respectively). A positive correlation was found between the recovery rate of p-aminobenzoic acid and the villous height (r = 0.52, P = 0.0001). The presence of K and L cells was verified in the duodenum and the jejunum. Conclusions: Close relationship between pancreas and small intestine was demonstrated.
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U2 - 10.1097/MPA.0000000000000426
DO - 10.1097/MPA.0000000000000426
M3 - Article
C2 - 26390418
AN - SCOPUS:84944394817
SN - 0885-3177
VL - 44
SP - 1352
EP - 1357
JO - Pancreas
JF - Pancreas
IS - 8
ER -
