Investigation on the Relalionship between Skin Diseases and VB2 Deficiency

Naoko Ito, Yoshimi Ninagawa, Kayoko Matsunaga, Ritsuko Hayakawa

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We studied on the relationship between skin diseases and VB2 deficiency by using erythrocyte glutathion reductase (EGR) activity method. The subjects were 68 cases with acne vulgaris, 16 cases with urticaria and 36 cases with atopic dermatitis. We measured EGR activity with and without FAD, serum total lipids, serum TBA, WBC, Hb and IgE to investigate the relationship among each data. We calculated FAD coefficiency by the following formula. FAD coefficient = (EGR activity with FAD/EGR activity without FAD) × 100. In acne vulgaris, the mean values and standard deviations of FAD coefficient were shown as 1.07±0.05 in mild cases, 1.15±0.11 in moderate and 1.21 ±0.08 in severe. Significant differences of FAD coefficient mean values were found among the three groups by analysis of valiance one way layout (p<0.05) and between mild cases and the other cases by Scheffé method (p<0.05). In urticaria, 6 out of 14 cases wiht moderate or severe symptom indicated higher values of FAD coefficient than 1.3 and this fact suggested that VB2 deficiency might be seen in the cases with moderate or severe urticaria.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
Journalskin research
Issue number3
Publication statusPublished - 01-01-1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases


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