Investigation on the Relalionship between Skin Diseases and VB₂ Deficiency

We studied on the relationship between skin diseases and VB₂ deficiency by using erythrocyte glutathion reductase (EGR) activity method. The subjects were 68 cases with acne vulgaris, 16 cases with urticaria and 36 cases with atopic dermatitis. We measured EGR activity with and without FAD, serum total lipids, serum TBA, WBC, Hb and IgE to investigate the relationship among each data. We calculated FAD coefficiency by the following formula. FAD coefficient = (EGR activity with FAD/EGR activity without FAD) × 100. In acne vulgaris, the mean values and standard deviations of FAD coefficient were shown as 1.07±0.05 in mild cases, 1.15±0.11 in moderate and 1.21 ±0.08 in severe. Significant differences of FAD coefficient mean values were found among the three groups by analysis of valiance one way layout (p<0.05) and between mild cases and the other cases by Scheffé method (p<0.05). In urticaria, 6 out of 14 cases wiht moderate or severe symptom indicated higher values of FAD coefficient than 1.3 and this fact suggested that VB₂ deficiency might be seen in the cases with moderate or severe urticaria.