TY - JOUR
T1 - Involvement of AChergic systems in chlordiazepoxide induced impairment of passive avoidance response
AU - Nabeshima, T.
AU - Tohyama, K.
AU - Kameyama, T.
PY - 1990/9/4
Y1 - 1990/9/4
N2 - The chlordiazepoxide (CDP)-induced impairment of the passive avoidance response was attenuated by Ro 15-4513, a benzodiazepine inverse agonist, physostigmine and scopolamine at low doses. In a biochemical approach, CDP increased, but Ro 15-4513 decreased the acetylcholine (ACh) levels of cerebral cortex. After the training of passive avoidance, the ACh levels in the hippocampus and cerebral cortex decreased. This change disappeared by pretraining administration of CDP. These results suggest that the effect of CDP on the passive avoidance response was related to AChergic neuronal systems.
AB - The chlordiazepoxide (CDP)-induced impairment of the passive avoidance response was attenuated by Ro 15-4513, a benzodiazepine inverse agonist, physostigmine and scopolamine at low doses. In a biochemical approach, CDP increased, but Ro 15-4513 decreased the acetylcholine (ACh) levels of cerebral cortex. After the training of passive avoidance, the ACh levels in the hippocampus and cerebral cortex decreased. This change disappeared by pretraining administration of CDP. These results suggest that the effect of CDP on the passive avoidance response was related to AChergic neuronal systems.
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U2 - 10.1016/0304-3940(90)90144-X
DO - 10.1016/0304-3940(90)90144-X
M3 - Article
C2 - 2290617
AN - SCOPUS:0025183619
SN - 0304-3940
VL - 117
SP - 200
EP - 206
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -