Involvement of AChergic systems in chlordiazepoxide induced impairment of passive avoidance response

T. Nabeshima; K. Tohyama; T. Kameyama

doi:10.1016/0304-3940(90)90144-X

Involvement of AChergic systems in chlordiazepoxide induced impairment of passive avoidance response

T. Nabeshima
, K. Tohyama
, T. Kameyama

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The chlordiazepoxide (CDP)-induced impairment of the passive avoidance response was attenuated by Ro 15-4513, a benzodiazepine inverse agonist, physostigmine and scopolamine at low doses. In a biochemical approach, CDP increased, but Ro 15-4513 decreased the acetylcholine (ACh) levels of cerebral cortex. After the training of passive avoidance, the ACh levels in the hippocampus and cerebral cortex decreased. This change disappeared by pretraining administration of CDP. These results suggest that the effect of CDP on the passive avoidance response was related to AChergic neuronal systems.

Original language	English
Pages (from-to)	200-206
Number of pages	7
Journal	Neuroscience Letters
Volume	117
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(90)90144-X
Publication status	Published - 04-09-1990
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

Access to Document

10.1016/0304-3940(90)90144-X

Cite this

@article{4c5220351e6a45feaccda08c5c781ba3,

title = "Involvement of AChergic systems in chlordiazepoxide induced impairment of passive avoidance response",

abstract = "The chlordiazepoxide (CDP)-induced impairment of the passive avoidance response was attenuated by Ro 15-4513, a benzodiazepine inverse agonist, physostigmine and scopolamine at low doses. In a biochemical approach, CDP increased, but Ro 15-4513 decreased the acetylcholine (ACh) levels of cerebral cortex. After the training of passive avoidance, the ACh levels in the hippocampus and cerebral cortex decreased. This change disappeared by pretraining administration of CDP. These results suggest that the effect of CDP on the passive avoidance response was related to AChergic neuronal systems.",

author = "T. Nabeshima and K. Tohyama and T. Kameyama",

year = "1990",

month = sep,

day = "4",

doi = "10.1016/0304-3940(90)90144-X",

language = "English",

volume = "117",

pages = "200--206",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Involvement of AChergic systems in chlordiazepoxide induced impairment of passive avoidance response

AU - Nabeshima, T.

AU - Tohyama, K.

AU - Kameyama, T.

PY - 1990/9/4

Y1 - 1990/9/4

N2 - The chlordiazepoxide (CDP)-induced impairment of the passive avoidance response was attenuated by Ro 15-4513, a benzodiazepine inverse agonist, physostigmine and scopolamine at low doses. In a biochemical approach, CDP increased, but Ro 15-4513 decreased the acetylcholine (ACh) levels of cerebral cortex. After the training of passive avoidance, the ACh levels in the hippocampus and cerebral cortex decreased. This change disappeared by pretraining administration of CDP. These results suggest that the effect of CDP on the passive avoidance response was related to AChergic neuronal systems.

AB - The chlordiazepoxide (CDP)-induced impairment of the passive avoidance response was attenuated by Ro 15-4513, a benzodiazepine inverse agonist, physostigmine and scopolamine at low doses. In a biochemical approach, CDP increased, but Ro 15-4513 decreased the acetylcholine (ACh) levels of cerebral cortex. After the training of passive avoidance, the ACh levels in the hippocampus and cerebral cortex decreased. This change disappeared by pretraining administration of CDP. These results suggest that the effect of CDP on the passive avoidance response was related to AChergic neuronal systems.

UR - https://www.scopus.com/pages/publications/0025183619

UR - https://www.scopus.com/pages/publications/0025183619#tab=citedBy

U2 - 10.1016/0304-3940(90)90144-X

DO - 10.1016/0304-3940(90)90144-X

M3 - Article

C2 - 2290617

AN - SCOPUS:0025183619

SN - 0304-3940

VL - 117

SP - 200

EP - 206

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

Involvement of AChergic systems in chlordiazepoxide induced impairment of passive avoidance response

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this