Involvement of Ca2+ in platelet-derived growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts

Terutaka Tsuda, Kozo Kaibuchi, Brian West, Yoshimi Takai

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Addition of platelet-derived growth factor (PDGF) to quiescent cultures of Swiss 3T3 fibroblasts rapidly increased the cytoplasmic free Ca2+ concentrations and afterwards the c-myc mRNA levels. The concentrations of PDGF needed for both reactions were roughly the same. Moreover, the Ca2+ ionophores, A23187 and ionomycin, mimicked the actions of PDGF and increased the c-myc mRNA levels. These results suggest that Ca2+ may be involved in the regulation of PDGF-induced expression of the c-myc gene.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalFEBS Letters
Volume187
Issue number1
DOIs
Publication statusPublished - 22-07-1985

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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