Involvement of Ca2+ in platelet-derived growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts

Terutaka Tsuda; Kozo Kaibuchi; Brian West; Yoshimi Takai

doi:10.1016/0014-5793(85)81210-2

Involvement of Ca²⁺ in platelet-derived growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts

Terutaka Tsuda, Kozo Kaibuchi, Brian West, Yoshimi Takai

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Addition of platelet-derived growth factor (PDGF) to quiescent cultures of Swiss 3T3 fibroblasts rapidly increased the cytoplasmic free Ca²⁺ concentrations and afterwards the c-myc mRNA levels. The concentrations of PDGF needed for both reactions were roughly the same. Moreover, the Ca²⁺ ionophores, A23187 and ionomycin, mimicked the actions of PDGF and increased the c-myc mRNA levels. These results suggest that Ca²⁺ may be involved in the regulation of PDGF-induced expression of the c-myc gene.

Original language	English
Pages (from-to)	43-46
Number of pages	4
Journal	FEBS Letters
Volume	187
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(85)81210-2
Publication status	Published - 22-07-1985
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(85)81210-2

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title = "Involvement of Ca2+ in platelet-derived growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts",

abstract = "Addition of platelet-derived growth factor (PDGF) to quiescent cultures of Swiss 3T3 fibroblasts rapidly increased the cytoplasmic free Ca2+ concentrations and afterwards the c-myc mRNA levels. The concentrations of PDGF needed for both reactions were roughly the same. Moreover, the Ca2+ ionophores, A23187 and ionomycin, mimicked the actions of PDGF and increased the c-myc mRNA levels. These results suggest that Ca2+ may be involved in the regulation of PDGF-induced expression of the c-myc gene.",

author = "Terutaka Tsuda and Kozo Kaibuchi and Brian West and Yoshimi Takai",

note = "Funding Information: of the Ministry of Education, Science and Culture, Japan (1984), Foundation for Promotion of Cancer Research (1984), the Naito Foundation (1984), and the Yamanouchi Foundation for Research on Metabolic Disorders (1984). The authors are grateful to Miss J. Yamaguchi for her skillful secretarial assistance.",

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doi = "10.1016/0014-5793(85)81210-2",

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T1 - Involvement of Ca2+ in platelet-derived growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts

AU - Tsuda, Terutaka

AU - Kaibuchi, Kozo

AU - West, Brian

AU - Takai, Yoshimi

N1 - Funding Information: of the Ministry of Education, Science and Culture, Japan (1984), Foundation for Promotion of Cancer Research (1984), the Naito Foundation (1984), and the Yamanouchi Foundation for Research on Metabolic Disorders (1984). The authors are grateful to Miss J. Yamaguchi for her skillful secretarial assistance.

PY - 1985/7/22

Y1 - 1985/7/22

N2 - Addition of platelet-derived growth factor (PDGF) to quiescent cultures of Swiss 3T3 fibroblasts rapidly increased the cytoplasmic free Ca2+ concentrations and afterwards the c-myc mRNA levels. The concentrations of PDGF needed for both reactions were roughly the same. Moreover, the Ca2+ ionophores, A23187 and ionomycin, mimicked the actions of PDGF and increased the c-myc mRNA levels. These results suggest that Ca2+ may be involved in the regulation of PDGF-induced expression of the c-myc gene.

AB - Addition of platelet-derived growth factor (PDGF) to quiescent cultures of Swiss 3T3 fibroblasts rapidly increased the cytoplasmic free Ca2+ concentrations and afterwards the c-myc mRNA levels. The concentrations of PDGF needed for both reactions were roughly the same. Moreover, the Ca2+ ionophores, A23187 and ionomycin, mimicked the actions of PDGF and increased the c-myc mRNA levels. These results suggest that Ca2+ may be involved in the regulation of PDGF-induced expression of the c-myc gene.

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Involvement of Ca²⁺ in platelet-derived growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts

Abstract

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