TY - JOUR
T1 - Involvement of dopaminergic system in the nucleus accumbens in the discriminative stimulus effects of phencyclidine
AU - Mori, Akitomo
AU - Noda, Yukihiro
AU - Nagai, Taku
AU - Mamiya, Takayoshi
AU - Furukawa, Hiroshi
AU - Nabeshima, Toshitaka
N1 - Funding Information:
This work was supported, in part, by a Grant-in-Aid for COE Research and Scientific Research (10044260) from the Ministry of Education, Science, Sports and Culture of Japan, by Special Coordination Funds for Promoting Science and Technology, the Target-oriented Brain Science Research Program, from the Ministry of Science and Technology of Japan and by Health Scientific Research Grants for Research on Pharmaceutical and Medical Safety from the Ministry of Health and Welfare of Japan.
PY - 2002
Y1 - 2002
N2 - The effects of microinjection of phencyclidine (PCP) and dizocilpine, non-competitive NMDA receptor antagonists, and dopamine into the nucleus accumbens were examined in rats trained to discriminate PCP (1.5 mg/kg i.p.) from saline under a two-lever fixed ratio 20 schedule of food reinforcement. Microinjection of PCP (2-40 μg) and dizocilpine (2-12 μg) into the bilateral nucleus accumbens produced a dose-dependent increase in PCP-appropriate responding and fully substituted for systemically administered PCP, whereas microinjection of dopamine (1-4 μg) did not produce PCP-like discriminative stimulus effects. The performance of PCP discrimination was assessed after bilateral destruction of the dopaminergic nerve neurons in the nucleus accumbens with dopaminergic neurotoxin, 6-hydroxydopamine (6-OHDA, 4 μg/1 μl/side). The destruction of dopaminergic nerve neurons in the nucleus accumbens failed to prevent the performance of PCP discrimination. There was no difference in the average percentages of PCP-appropriate responding between vehicle and 6-OHDA-treated rats in the dose-response tests. These results suggest that the dopaminergic system in the nucleus accumbens does not play a critical role in the discriminative stimulus effects of PCP.
AB - The effects of microinjection of phencyclidine (PCP) and dizocilpine, non-competitive NMDA receptor antagonists, and dopamine into the nucleus accumbens were examined in rats trained to discriminate PCP (1.5 mg/kg i.p.) from saline under a two-lever fixed ratio 20 schedule of food reinforcement. Microinjection of PCP (2-40 μg) and dizocilpine (2-12 μg) into the bilateral nucleus accumbens produced a dose-dependent increase in PCP-appropriate responding and fully substituted for systemically administered PCP, whereas microinjection of dopamine (1-4 μg) did not produce PCP-like discriminative stimulus effects. The performance of PCP discrimination was assessed after bilateral destruction of the dopaminergic nerve neurons in the nucleus accumbens with dopaminergic neurotoxin, 6-hydroxydopamine (6-OHDA, 4 μg/1 μl/side). The destruction of dopaminergic nerve neurons in the nucleus accumbens failed to prevent the performance of PCP discrimination. There was no difference in the average percentages of PCP-appropriate responding between vehicle and 6-OHDA-treated rats in the dose-response tests. These results suggest that the dopaminergic system in the nucleus accumbens does not play a critical role in the discriminative stimulus effects of PCP.
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U2 - 10.1016/S0028-3908(02)00037-0
DO - 10.1016/S0028-3908(02)00037-0
M3 - Article
C2 - 12015202
AN - SCOPUS:0036095506
SN - 0028-3908
VL - 42
SP - 764
EP - 771
JO - Neuropharmacology
JF - Neuropharmacology
IS - 6
ER -