Involvement of dopaminergic system in the nucleus accumbens in the discriminative stimulus effects of phencyclidine

Akitomo Mori, Yukihiro Noda, Taku Nagai, Takayoshi Mamiya, Hiroshi Furukawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of microinjection of phencyclidine (PCP) and dizocilpine, non-competitive NMDA receptor antagonists, and dopamine into the nucleus accumbens were examined in rats trained to discriminate PCP (1.5 mg/kg i.p.) from saline under a two-lever fixed ratio 20 schedule of food reinforcement. Microinjection of PCP (2-40 μg) and dizocilpine (2-12 μg) into the bilateral nucleus accumbens produced a dose-dependent increase in PCP-appropriate responding and fully substituted for systemically administered PCP, whereas microinjection of dopamine (1-4 μg) did not produce PCP-like discriminative stimulus effects. The performance of PCP discrimination was assessed after bilateral destruction of the dopaminergic nerve neurons in the nucleus accumbens with dopaminergic neurotoxin, 6-hydroxydopamine (6-OHDA, 4 μg/1 μl/side). The destruction of dopaminergic nerve neurons in the nucleus accumbens failed to prevent the performance of PCP discrimination. There was no difference in the average percentages of PCP-appropriate responding between vehicle and 6-OHDA-treated rats in the dose-response tests. These results suggest that the dopaminergic system in the nucleus accumbens does not play a critical role in the discriminative stimulus effects of PCP.

Original languageEnglish
Pages (from-to)764-771
Number of pages8
JournalNeuropharmacology
Volume42
Issue number6
DOIs
Publication statusPublished - 27-05-2002
Externally publishedYes

Fingerprint

Phencyclidine
Nucleus Accumbens
Oxidopamine
Microinjections
Dizocilpine Maleate
Dopaminergic Neurons
Reinforcement Schedule
Dopamine Antagonists
Neurotoxins
N-Methyl-D-Aspartate Receptors
Dopamine
Food

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Mori, Akitomo ; Noda, Yukihiro ; Nagai, Taku ; Mamiya, Takayoshi ; Furukawa, Hiroshi ; Nabeshima, Toshitaka. / Involvement of dopaminergic system in the nucleus accumbens in the discriminative stimulus effects of phencyclidine. In: Neuropharmacology. 2002 ; Vol. 42, No. 6. pp. 764-771.
@article{150b9ad7071a4bfa94a4806ce8fbaa76,
title = "Involvement of dopaminergic system in the nucleus accumbens in the discriminative stimulus effects of phencyclidine",
abstract = "The effects of microinjection of phencyclidine (PCP) and dizocilpine, non-competitive NMDA receptor antagonists, and dopamine into the nucleus accumbens were examined in rats trained to discriminate PCP (1.5 mg/kg i.p.) from saline under a two-lever fixed ratio 20 schedule of food reinforcement. Microinjection of PCP (2-40 μg) and dizocilpine (2-12 μg) into the bilateral nucleus accumbens produced a dose-dependent increase in PCP-appropriate responding and fully substituted for systemically administered PCP, whereas microinjection of dopamine (1-4 μg) did not produce PCP-like discriminative stimulus effects. The performance of PCP discrimination was assessed after bilateral destruction of the dopaminergic nerve neurons in the nucleus accumbens with dopaminergic neurotoxin, 6-hydroxydopamine (6-OHDA, 4 μg/1 μl/side). The destruction of dopaminergic nerve neurons in the nucleus accumbens failed to prevent the performance of PCP discrimination. There was no difference in the average percentages of PCP-appropriate responding between vehicle and 6-OHDA-treated rats in the dose-response tests. These results suggest that the dopaminergic system in the nucleus accumbens does not play a critical role in the discriminative stimulus effects of PCP.",
author = "Akitomo Mori and Yukihiro Noda and Taku Nagai and Takayoshi Mamiya and Hiroshi Furukawa and Toshitaka Nabeshima",
year = "2002",
month = "5",
day = "27",
doi = "10.1016/S0028-3908(02)00037-0",
language = "English",
volume = "42",
pages = "764--771",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier Limited",
number = "6",

}

Involvement of dopaminergic system in the nucleus accumbens in the discriminative stimulus effects of phencyclidine. / Mori, Akitomo; Noda, Yukihiro; Nagai, Taku; Mamiya, Takayoshi; Furukawa, Hiroshi; Nabeshima, Toshitaka.

In: Neuropharmacology, Vol. 42, No. 6, 27.05.2002, p. 764-771.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Involvement of dopaminergic system in the nucleus accumbens in the discriminative stimulus effects of phencyclidine

AU - Mori, Akitomo

AU - Noda, Yukihiro

AU - Nagai, Taku

AU - Mamiya, Takayoshi

AU - Furukawa, Hiroshi

AU - Nabeshima, Toshitaka

PY - 2002/5/27

Y1 - 2002/5/27

N2 - The effects of microinjection of phencyclidine (PCP) and dizocilpine, non-competitive NMDA receptor antagonists, and dopamine into the nucleus accumbens were examined in rats trained to discriminate PCP (1.5 mg/kg i.p.) from saline under a two-lever fixed ratio 20 schedule of food reinforcement. Microinjection of PCP (2-40 μg) and dizocilpine (2-12 μg) into the bilateral nucleus accumbens produced a dose-dependent increase in PCP-appropriate responding and fully substituted for systemically administered PCP, whereas microinjection of dopamine (1-4 μg) did not produce PCP-like discriminative stimulus effects. The performance of PCP discrimination was assessed after bilateral destruction of the dopaminergic nerve neurons in the nucleus accumbens with dopaminergic neurotoxin, 6-hydroxydopamine (6-OHDA, 4 μg/1 μl/side). The destruction of dopaminergic nerve neurons in the nucleus accumbens failed to prevent the performance of PCP discrimination. There was no difference in the average percentages of PCP-appropriate responding between vehicle and 6-OHDA-treated rats in the dose-response tests. These results suggest that the dopaminergic system in the nucleus accumbens does not play a critical role in the discriminative stimulus effects of PCP.

AB - The effects of microinjection of phencyclidine (PCP) and dizocilpine, non-competitive NMDA receptor antagonists, and dopamine into the nucleus accumbens were examined in rats trained to discriminate PCP (1.5 mg/kg i.p.) from saline under a two-lever fixed ratio 20 schedule of food reinforcement. Microinjection of PCP (2-40 μg) and dizocilpine (2-12 μg) into the bilateral nucleus accumbens produced a dose-dependent increase in PCP-appropriate responding and fully substituted for systemically administered PCP, whereas microinjection of dopamine (1-4 μg) did not produce PCP-like discriminative stimulus effects. The performance of PCP discrimination was assessed after bilateral destruction of the dopaminergic nerve neurons in the nucleus accumbens with dopaminergic neurotoxin, 6-hydroxydopamine (6-OHDA, 4 μg/1 μl/side). The destruction of dopaminergic nerve neurons in the nucleus accumbens failed to prevent the performance of PCP discrimination. There was no difference in the average percentages of PCP-appropriate responding between vehicle and 6-OHDA-treated rats in the dose-response tests. These results suggest that the dopaminergic system in the nucleus accumbens does not play a critical role in the discriminative stimulus effects of PCP.

UR - http://www.scopus.com/inward/record.url?scp=0036095506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036095506&partnerID=8YFLogxK

U2 - 10.1016/S0028-3908(02)00037-0

DO - 10.1016/S0028-3908(02)00037-0

M3 - Article

C2 - 12015202

AN - SCOPUS:0036095506

VL - 42

SP - 764

EP - 771

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 6

ER -