Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells

Hiroaki Kajiyama; Kiyosumi Shibata; Mikio Terauchi; Kazuhiko Ino; Akihiro Nawa; Fumitaka Kikkawa

doi:10.1196/annals.1377.007

Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells

Hiroaki Kajiyama, Kiyosumi Shibata, Mikio Terauchi, Kazuhiko Ino, Akihiro Nawa, Fumitaka Kikkawa

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

11 Citations (Scopus)

Abstract

Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression and it has a variety of functional properties in the development of human malignancies. In the present study, we showed the possible correlation between DPPIV/CD26 expression and less migratory potential with decreased MMP-2 expression in ovarian carcinoma cells. Moreover, induction of DPPIV/CD26 resulted in reduced expressions of MMP-2 and mesenchymal markers such as vimentin and SMA, with a less invasive potential and an epithelial morphologic change. This evidence implies that DPPIV/CD26 may play a crucial role in the antimetastatic potential in ovarian carcinoma.

Original language	English
Title of host publication	Integrated Molecular Medicine for Neuronal and Neoplastic Disorders
Publisher	Blackwell Publishing Inc.
Pages	233-240
Number of pages	8
ISBN (Print)	1573316555, 9781573316552
DOIs	https://doi.org/10.1196/annals.1377.007
Publication status	Published - 11-2006
Externally published	Yes

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1086
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
History and Philosophy of Science

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10.1196/annals.1377.007

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Kajiyama, H., Shibata, K., Terauchi, M., Ino, K., Nawa, A., & Kikkawa, F. (2006). Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells. In Integrated Molecular Medicine for Neuronal and Neoplastic Disorders (pp. 233-240). (Annals of the New York Academy of Sciences; Vol. 1086). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1377.007

@inproceedings{42ac7c31a07d46728a702234eee003d0,

title = "Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells",

abstract = "Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression and it has a variety of functional properties in the development of human malignancies. In the present study, we showed the possible correlation between DPPIV/CD26 expression and less migratory potential with decreased MMP-2 expression in ovarian carcinoma cells. Moreover, induction of DPPIV/CD26 resulted in reduced expressions of MMP-2 and mesenchymal markers such as vimentin and SMA, with a less invasive potential and an epithelial morphologic change. This evidence implies that DPPIV/CD26 may play a crucial role in the antimetastatic potential in ovarian carcinoma.",

author = "Hiroaki Kajiyama and Kiyosumi Shibata and Mikio Terauchi and Kazuhiko Ino and Akihiro Nawa and Fumitaka Kikkawa",

year = "2006",

month = nov,

doi = "10.1196/annals.1377.007",

language = "English",

isbn = "1573316555",

series = "Annals of the New York Academy of Sciences",

publisher = "Blackwell Publishing Inc.",

pages = "233--240",

booktitle = "Integrated Molecular Medicine for Neuronal and Neoplastic Disorders",

}

Kajiyama, H, Shibata, K, Terauchi, M, Ino, K, Nawa, A & Kikkawa, F 2006, Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells. in Integrated Molecular Medicine for Neuronal and Neoplastic Disorders. Annals of the New York Academy of Sciences, vol. 1086, Blackwell Publishing Inc., pp. 233-240. https://doi.org/10.1196/annals.1377.007

Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells. / Kajiyama, Hiroaki; Shibata, Kiyosumi; Terauchi, Mikio et al.
Integrated Molecular Medicine for Neuronal and Neoplastic Disorders. Blackwell Publishing Inc., 2006. p. 233-240 (Annals of the New York Academy of Sciences; Vol. 1086).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells

AU - Kajiyama, Hiroaki

AU - Shibata, Kiyosumi

AU - Terauchi, Mikio

AU - Ino, Kazuhiko

AU - Nawa, Akihiro

AU - Kikkawa, Fumitaka

PY - 2006/11

Y1 - 2006/11

N2 - Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression and it has a variety of functional properties in the development of human malignancies. In the present study, we showed the possible correlation between DPPIV/CD26 expression and less migratory potential with decreased MMP-2 expression in ovarian carcinoma cells. Moreover, induction of DPPIV/CD26 resulted in reduced expressions of MMP-2 and mesenchymal markers such as vimentin and SMA, with a less invasive potential and an epithelial morphologic change. This evidence implies that DPPIV/CD26 may play a crucial role in the antimetastatic potential in ovarian carcinoma.

AB - Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression and it has a variety of functional properties in the development of human malignancies. In the present study, we showed the possible correlation between DPPIV/CD26 expression and less migratory potential with decreased MMP-2 expression in ovarian carcinoma cells. Moreover, induction of DPPIV/CD26 resulted in reduced expressions of MMP-2 and mesenchymal markers such as vimentin and SMA, with a less invasive potential and an epithelial morphologic change. This evidence implies that DPPIV/CD26 may play a crucial role in the antimetastatic potential in ovarian carcinoma.

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DO - 10.1196/annals.1377.007

M3 - Conference contribution

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AN - SCOPUS:34447526600

SN - 1573316555

SN - 9781573316552

T3 - Annals of the New York Academy of Sciences

SP - 233

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BT - Integrated Molecular Medicine for Neuronal and Neoplastic Disorders

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ER -

Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells

Abstract

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