Abstract
The possible involvement of GABAergic neuronal systems in benzodiazepine(BZP)-induced impairment of a passive avoidance response was investigated. Chlordiazepoxide(CDP) impaired passive avoidance when administered prior to training. The CDP-induced impairment was antagonized by pretreatment with picrotoxin, but not by pretreatment with bicuculline or posttraining administration of picrotoxin. On the contrary, when combined with muscimol, the dose at which CDP impaired the response was lower than the dose at which it did so alone. The synergy of muscimol and CDP was attenuated by pretreatment with flumazenil or bicuculline. From these results, we conclude that GABAergic systems play an important role in the BZP-induced impairment of passive avoidance.
| Original language | English |
|---|---|
| Pages (from-to) | 22-26 |
| Number of pages | 5 |
| Journal | Psychopharmacology |
| Volume | 105 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 01-03-1991 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice. / Tohyama, Keiko; Nabeshima, Toshitaka; Ichihara, Kenji; Kameyama, Tsutomu.
In: Psychopharmacology, Vol. 105, No. 1, 01.03.1991, p. 22-26.Research output: Contribution to journal › Article
TY - JOUR
T1 - Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice
AU - Tohyama, Keiko
AU - Nabeshima, Toshitaka
AU - Ichihara, Kenji
AU - Kameyama, Tsutomu
PY - 1991/3/1
Y1 - 1991/3/1
N2 - The possible involvement of GABAergic neuronal systems in benzodiazepine(BZP)-induced impairment of a passive avoidance response was investigated. Chlordiazepoxide(CDP) impaired passive avoidance when administered prior to training. The CDP-induced impairment was antagonized by pretreatment with picrotoxin, but not by pretreatment with bicuculline or posttraining administration of picrotoxin. On the contrary, when combined with muscimol, the dose at which CDP impaired the response was lower than the dose at which it did so alone. The synergy of muscimol and CDP was attenuated by pretreatment with flumazenil or bicuculline. From these results, we conclude that GABAergic systems play an important role in the BZP-induced impairment of passive avoidance.
AB - The possible involvement of GABAergic neuronal systems in benzodiazepine(BZP)-induced impairment of a passive avoidance response was investigated. Chlordiazepoxide(CDP) impaired passive avoidance when administered prior to training. The CDP-induced impairment was antagonized by pretreatment with picrotoxin, but not by pretreatment with bicuculline or posttraining administration of picrotoxin. On the contrary, when combined with muscimol, the dose at which CDP impaired the response was lower than the dose at which it did so alone. The synergy of muscimol and CDP was attenuated by pretreatment with flumazenil or bicuculline. From these results, we conclude that GABAergic systems play an important role in the BZP-induced impairment of passive avoidance.
UR - http://www.scopus.com/inward/record.url?scp=0025887108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025887108&partnerID=8YFLogxK
U2 - 10.1007/BF02316859
DO - 10.1007/BF02316859
M3 - Article
C2 - 1684058
AN - SCOPUS:0025887108
VL - 105
SP - 22
EP - 26
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 1
ER -