Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice

Keiko Tohyama; Toshitaka Nabeshima; Kenji Ichihara; Tsutomu Kameyama

doi:10.1007/BF02316859

Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice

Keiko Tohyama, Toshitaka Nabeshima, Kenji Ichihara, Tsutomu Kameyama

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The possible involvement of GABAergic neuronal systems in benzodiazepine(BZP)-induced impairment of a passive avoidance response was investigated. Chlordiazepoxide(CDP) impaired passive avoidance when administered prior to training. The CDP-induced impairment was antagonized by pretreatment with picrotoxin, but not by pretreatment with bicuculline or posttraining administration of picrotoxin. On the contrary, when combined with muscimol, the dose at which CDP impaired the response was lower than the dose at which it did so alone. The synergy of muscimol and CDP was attenuated by pretreatment with flumazenil or bicuculline. From these results, we conclude that GABAergic systems play an important role in the BZP-induced impairment of passive avoidance.

Original language	English
Pages (from-to)	22-26
Number of pages	5
Journal	Psychopharmacology
Volume	105
Issue number	1
DOIs	https://doi.org/10.1007/BF02316859
Publication status	Published - 01-03-1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1007/BF02316859

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abstract = "The possible involvement of GABAergic neuronal systems in benzodiazepine(BZP)-induced impairment of a passive avoidance response was investigated. Chlordiazepoxide(CDP) impaired passive avoidance when administered prior to training. The CDP-induced impairment was antagonized by pretreatment with picrotoxin, but not by pretreatment with bicuculline or posttraining administration of picrotoxin. On the contrary, when combined with muscimol, the dose at which CDP impaired the response was lower than the dose at which it did so alone. The synergy of muscimol and CDP was attenuated by pretreatment with flumazenil or bicuculline. From these results, we conclude that GABAergic systems play an important role in the BZP-induced impairment of passive avoidance.",

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AU - Kameyama, Tsutomu

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Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice

Abstract

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