Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice

Keiko Tohyama, Toshitaka Nabeshima, Kenji Ichihara, Tsutomu Kameyama

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The possible involvement of GABAergic neuronal systems in benzodiazepine(BZP)-induced impairment of a passive avoidance response was investigated. Chlordiazepoxide(CDP) impaired passive avoidance when administered prior to training. The CDP-induced impairment was antagonized by pretreatment with picrotoxin, but not by pretreatment with bicuculline or posttraining administration of picrotoxin. On the contrary, when combined with muscimol, the dose at which CDP impaired the response was lower than the dose at which it did so alone. The synergy of muscimol and CDP was attenuated by pretreatment with flumazenil or bicuculline. From these results, we conclude that GABAergic systems play an important role in the BZP-induced impairment of passive avoidance.

Original languageEnglish
Pages (from-to)22-26
Number of pages5
JournalPsychopharmacology
Volume105
Issue number1
DOIs
Publication statusPublished - 01-03-1991
Externally publishedYes

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Avoidance Learning
Chlordiazepoxide
Benzodiazepines
Picrotoxin
Muscimol
Bicuculline
Flumazenil

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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abstract = "The possible involvement of GABAergic neuronal systems in benzodiazepine(BZP)-induced impairment of a passive avoidance response was investigated. Chlordiazepoxide(CDP) impaired passive avoidance when administered prior to training. The CDP-induced impairment was antagonized by pretreatment with picrotoxin, but not by pretreatment with bicuculline or posttraining administration of picrotoxin. On the contrary, when combined with muscimol, the dose at which CDP impaired the response was lower than the dose at which it did so alone. The synergy of muscimol and CDP was attenuated by pretreatment with flumazenil or bicuculline. From these results, we conclude that GABAergic systems play an important role in the BZP-induced impairment of passive avoidance.",
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Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice. / Tohyama, Keiko; Nabeshima, Toshitaka; Ichihara, Kenji; Kameyama, Tsutomu.

In: Psychopharmacology, Vol. 105, No. 1, 01.03.1991, p. 22-26.

Research output: Contribution to journalArticle

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