Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: Cytoprotective action of carbon monoxide

K. Shimizu, S. J. Bae, T. Hara, Y. Iwata, T. Yamaoka, K. Komura, E. Muroi, M. Takenaka, F. Ogawa, S. Sato

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The deposition of immune complexes (IC) induces an acute inflammatory response with tissue injury, for which the involvement of nitric oxide (NO) and carbon monoxide (CO) has been suggested. NO is induced by NO synthase (NOS) and CO is generated by haeme oxygenase (HO). Among HO isoenzymes, HO-1 is an induced type. To assess the role of NO and CO in the pathogenic process, the cutaneous reverse passive Arthus reaction was examined using NOS inhibitor, HO-1 stimulator and HO-1 inhibitor. To evaluate the reaction we considered oedema, tumour necrosis factor-α, interleukin-6, and neutrophil number. The values of these four parameters were significantly reduced in mice treated with HO-1 stimulator as compared with the positive control mice. Quite the reverse was observed in mice treated with HO-1 inhibitor. These results suggest that the HO-1/CO signalling pathway is a therapeutic target for human IC-mediated disease.

Original languageEnglish
Pages (from-to)245-257
Number of pages13
JournalClinical and Experimental Immunology
Volume153
Issue number2
DOIs
Publication statusPublished - 08-2008

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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