TY - JOUR
T1 - Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats
AU - Nagai, Taku
AU - Kamei, Hiroyuki
AU - Dohniwa, Misato
AU - Takayanagi, Masanori
AU - Suzuki, Masakazu
AU - Matsuya, Takahiro
AU - Nabeshima, Toshitaka
AU - Takuma, Kazuhiro
AU - Yamada, Kiyofumi
PY - 2006/9
Y1 - 2006/9
N2 - The role of the phosphorylation of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats was assessed with a delayed spatial win-shift task in a radial arm maze. The task consisted of two phases, a training phase and a test phase, separated by a delay. Phosphorylated extracellular signal-regulated kinase 1/2 levels were significantly and transiently increased in the hippocampus by 60 min, and then returned to the control levels 120 min after the training phase. Bilateral microinjections of the PD98059, an inhibitor of the extracellular signal-regulated kinase 1/2 kinase MEK, into the hippocampus impaired performance in the test phase of the delayed spatial win-shift task at 5-min delay. These results suggest that extracellular signal-regulated kinase 1/2 activation in the hippocampus plays a crucial role in spatial working memory.
AB - The role of the phosphorylation of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats was assessed with a delayed spatial win-shift task in a radial arm maze. The task consisted of two phases, a training phase and a test phase, separated by a delay. Phosphorylated extracellular signal-regulated kinase 1/2 levels were significantly and transiently increased in the hippocampus by 60 min, and then returned to the control levels 120 min after the training phase. Bilateral microinjections of the PD98059, an inhibitor of the extracellular signal-regulated kinase 1/2 kinase MEK, into the hippocampus impaired performance in the test phase of the delayed spatial win-shift task at 5-min delay. These results suggest that extracellular signal-regulated kinase 1/2 activation in the hippocampus plays a crucial role in spatial working memory.
UR - http://www.scopus.com/inward/record.url?scp=33748055747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748055747&partnerID=8YFLogxK
U2 - 10.1097/01.wnr.0000233095.74913.88
DO - 10.1097/01.wnr.0000233095.74913.88
M3 - Article
C2 - 16932157
AN - SCOPUS:33748055747
SN - 0959-4965
VL - 17
SP - 1453
EP - 1457
JO - Neuroreport
JF - Neuroreport
IS - 13
ER -