Involvement of Opioid Receptors in Hypo- and Hyperthermic Effects Induced By Phencyclidine in Mice

Masayuki Hiramatsu, Toshitaka Nabeshima, Tsutomu Kameyama

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Experiments were conducted in order to examine the mechanism of changes in body temperature induced by phencyclidine (PCP) in mice. It is well known that morphine changes body temperature in a biphasic manner. PCP also produced hyperthermia at low doses (5 and 10 mg/kg) and hypothermia at high dose (40 mg/kg). The changes in body temperature induced by PCP were blocked by naloxone, a mu antagonist. Pretreatment with morphine (2.5 mg/kg), a mu agonist, or ethylketocyclazocine (EKC: 2.5 mg/kg), a kappa agonist, potentiated hypothermia induced by high dose of PCP. Effects of morphine and EKC on PCP-induced hypothermia were antagonized by naloxone. N- Allylnormetazocine (SKF 10 047: 20 mg/kg), a kappa and mu antagonist, antagonized PCP - and EKC + PCP-induced hypothermia but not morphine + PCP-induced hypothermia. Furthermore, Mr 2266, a kappa antagonist, antagonized PCP (lOmg/kg)- induced hyperthermia and EKC + PCP-induced hypothermia. It is suggested that PCP may affect thermoregulation through mu and/or kappa opioid receptor mechanisms.

Original languageEnglish
Pages (from-to)466-472
Number of pages7
JournalJournal of Pharmacobio-Dynamics
Volume9
Issue number5
DOIs
Publication statusPublished - 01-01-1986
Externally publishedYes

Fingerprint

Induced Hypothermia
Phencyclidine
Opioid Receptors
Body Temperature Changes
Morphine
Naloxone
Ethylketocyclazocine
kappa Opioid Receptor
Induced Hyperthermia
Body Temperature Regulation
mu Opioid Receptor
Hypothermia
Fever

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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title = "Involvement of Opioid Receptors in Hypo- and Hyperthermic Effects Induced By Phencyclidine in Mice",
abstract = "Experiments were conducted in order to examine the mechanism of changes in body temperature induced by phencyclidine (PCP) in mice. It is well known that morphine changes body temperature in a biphasic manner. PCP also produced hyperthermia at low doses (5 and 10 mg/kg) and hypothermia at high dose (40 mg/kg). The changes in body temperature induced by PCP were blocked by naloxone, a mu antagonist. Pretreatment with morphine (2.5 mg/kg), a mu agonist, or ethylketocyclazocine (EKC: 2.5 mg/kg), a kappa agonist, potentiated hypothermia induced by high dose of PCP. Effects of morphine and EKC on PCP-induced hypothermia were antagonized by naloxone. N- Allylnormetazocine (SKF 10 047: 20 mg/kg), a kappa and mu antagonist, antagonized PCP - and EKC + PCP-induced hypothermia but not morphine + PCP-induced hypothermia. Furthermore, Mr 2266, a kappa antagonist, antagonized PCP (lOmg/kg)- induced hyperthermia and EKC + PCP-induced hypothermia. It is suggested that PCP may affect thermoregulation through mu and/or kappa opioid receptor mechanisms.",
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Involvement of Opioid Receptors in Hypo- and Hyperthermic Effects Induced By Phencyclidine in Mice. / Hiramatsu, Masayuki; Nabeshima, Toshitaka; Kameyama, Tsutomu.

In: Journal of Pharmacobio-Dynamics, Vol. 9, No. 5, 01.01.1986, p. 466-472.

Research output: Contribution to journalArticle

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