Involvement of oxidative stress in the accelerated formation of pentosidine in patients with end-stage renal failure

Zhe Cai, Toru Shinzato, Yoshihiro Matsumoto, Masamiki Miwa, Hiroko Otani, Shigeru Nakai, Jun Usami, Hirobumi Oka, Ichiro Takai, Kenji Maeda

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Advanced glycation end products (AGEs) have been found to accumulate in the amyloid deposits, skin and plasma of haemodialysis patients (HD), implicating the possible involvement of AGE-modified protein in pathogenesis in dialysis-related amyloidosis. Pentosidine, an AGE cross-link, is a specific marker for AGEs. Plasma pentosidine levels in HD patients were increased dramatically. In the present study, plasma pentosidine, fructoselysine, advanced oxidation protein products (AOPP) and glutathione peroxidase (GSHPx) levels were measured to elucidate the role of oxidative stress in pentosidine formation in nondiabetic HD patients. Plasma pentosidine did not correlate with fructoselysine; plasma AOPP levels were significantly higher than those in normal subjects (201.45 ± 57.93 vs. 55.91 ± 6.57 μmol/L, P < 0.001) and correlated positively with plasma pentosidine in HD patients (r = 0.52, P < 0.005); plasma GSHPx levels were significantly lower than those in normal subjects (168.40 ± 65.08 vs. 348.87 ± 86.10 U/l, P < .001) and correlated negatively with plasma pentosidine (r = 0.54, P < 0.001) in HD patients. Decreased GSHPx levels may lead to the accumulation of hydrogen peroxide. These findings implicate the involvement of oxidative stress in the accelerated formation of pentosidine in uraemia and suggest that pentosidine could be considered as an oxidative stress biomarker to estimate the degree of oxidative-stress-mediated protein damage.

Original languageEnglish
Pages (from-to)407-412
Number of pages6
JournalNephrology
Volume4
Issue number5-6
DOIs
Publication statusPublished - 01-01-1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Nephrology

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