Involvement of serotonergic neuronal systems in the anti-amnesic action of naftidrofuryl oxalate

Toshitaka Nabeshima, Ichihara Kenji, Tohyama Keiro, Murase Kenshi, Suzuki Takako, Kameyama Tsutomu

Research output: Contribution to journalArticle

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Abstract

The effects of naftidrofuryl oxalate on cycloheximide- and 5-hydroxytryptophan (5-HTP)-induced amnesia were investigated using a passive avoidance task in mice. Naftidrofuryl oxalate significantly improved the cycloheximide-induced amnesia. This effect of naftidrofuryl oxalate was antagonized by 5-HTP, a serotonin (5-HT) precursor, and by p-chloroamphetamine (PCA), a 5-HT releaser. Single administration of 5-HTP in combination with pargyline, a monoamine oxidase inhibitor, induced amnesia (5-HTP-induced amnesia). This amnesia was attenuated by ritanserin, a 5-HT2-selective antagonist, but not by pindolol a 5-HT1-selective antagonist. Naftidrofuryl oxalate also attenuated the 5-HTP-induced amnesia. A binding study reveaied that naftidrofuryl oxalate inhibited the binding of [3H]ketanserin to 5-HT2 receptors in mouse brain synaptic membrane in a dose-dependent fashion (IC50 = 1.42 × 10-7 M), but did not inhibit that of [3H]serotonin to 5-HT1 receptors. These resu suggest that naftidrofuryl oxalate may attenuate cycloheximide- and 5-HTP-induced amnesia by blocking 5-HT2 receptor subtypes.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalEuropean Journal of Pharmacology
Volume205
Issue number1
DOIs
Publication statusPublished - 19-11-1991

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Nafronyl
Amnesia
Oxalates
5-Hydroxytryptophan
Cycloheximide
Serotonin
p-Chloroamphetamine
Serotonin 5-HT1 Receptors
Ritanserin
Serotonin 5-HT1 Receptor Antagonists
Pargyline
Serotonin 5-HT2 Receptor Antagonists
Pindolol
Ketanserin
Synaptic Membranes
Monoamine Oxidase Inhibitors
Inhibitory Concentration 50
Brain

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Nabeshima, Toshitaka ; Kenji, Ichihara ; Keiro, Tohyama ; Kenshi, Murase ; Takako, Suzuki ; Tsutomu, Kameyama. / Involvement of serotonergic neuronal systems in the anti-amnesic action of naftidrofuryl oxalate. In: European Journal of Pharmacology. 1991 ; Vol. 205, No. 1. pp. 55-61.
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Involvement of serotonergic neuronal systems in the anti-amnesic action of naftidrofuryl oxalate. / Nabeshima, Toshitaka; Kenji, Ichihara; Keiro, Tohyama; Kenshi, Murase; Takako, Suzuki; Tsutomu, Kameyama.

In: European Journal of Pharmacology, Vol. 205, No. 1, 19.11.1991, p. 55-61.

Research output: Contribution to journalArticle

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