TY - JOUR
T1 - Involvement of serotonergic neuronal systems in the anti-amnesic action of naftidrofuryl oxalate
AU - Toshitaka, Nabeshima
AU - Kenji, Ichihara
AU - Keiro, Tohyama
AU - Kenshi, Murase
AU - Takako, Suzuki
AU - Tsutomu, Kameyama
PY - 1991/11/19
Y1 - 1991/11/19
N2 - The effects of naftidrofuryl oxalate on cycloheximide- and 5-hydroxytryptophan (5-HTP)-induced amnesia were investigated using a passive avoidance task in mice. Naftidrofuryl oxalate significantly improved the cycloheximide-induced amnesia. This effect of naftidrofuryl oxalate was antagonized by 5-HTP, a serotonin (5-HT) precursor, and by p-chloroamphetamine (PCA), a 5-HT releaser. Single administration of 5-HTP in combination with pargyline, a monoamine oxidase inhibitor, induced amnesia (5-HTP-induced amnesia). This amnesia was attenuated by ritanserin, a 5-HT2-selective antagonist, but not by pindolol a 5-HT1-selective antagonist. Naftidrofuryl oxalate also attenuated the 5-HTP-induced amnesia. A binding study reveaied that naftidrofuryl oxalate inhibited the binding of [3H]ketanserin to 5-HT2 receptors in mouse brain synaptic membrane in a dose-dependent fashion (IC50 = 1.42 × 10-7 M), but did not inhibit that of [3H]serotonin to 5-HT1 receptors. These resu suggest that naftidrofuryl oxalate may attenuate cycloheximide- and 5-HTP-induced amnesia by blocking 5-HT2 receptor subtypes.
AB - The effects of naftidrofuryl oxalate on cycloheximide- and 5-hydroxytryptophan (5-HTP)-induced amnesia were investigated using a passive avoidance task in mice. Naftidrofuryl oxalate significantly improved the cycloheximide-induced amnesia. This effect of naftidrofuryl oxalate was antagonized by 5-HTP, a serotonin (5-HT) precursor, and by p-chloroamphetamine (PCA), a 5-HT releaser. Single administration of 5-HTP in combination with pargyline, a monoamine oxidase inhibitor, induced amnesia (5-HTP-induced amnesia). This amnesia was attenuated by ritanserin, a 5-HT2-selective antagonist, but not by pindolol a 5-HT1-selective antagonist. Naftidrofuryl oxalate also attenuated the 5-HTP-induced amnesia. A binding study reveaied that naftidrofuryl oxalate inhibited the binding of [3H]ketanserin to 5-HT2 receptors in mouse brain synaptic membrane in a dose-dependent fashion (IC50 = 1.42 × 10-7 M), but did not inhibit that of [3H]serotonin to 5-HT1 receptors. These resu suggest that naftidrofuryl oxalate may attenuate cycloheximide- and 5-HTP-induced amnesia by blocking 5-HT2 receptor subtypes.
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U2 - 10.1016/0014-2999(91)90770-Q
DO - 10.1016/0014-2999(91)90770-Q
M3 - Article
C2 - 1811997
AN - SCOPUS:0026047231
SN - 0014-2999
VL - 205
SP - 55
EP - 61
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -