Abstract
The site of action of tizanidine (5-chloro-4-(2-imidazolin-2-yl-amino)2,1,3-benzothiadiazole) was investigated in a tail-flick test in comparison with clonidine and morphine. Tizanidine and clonidine produced a profound and linear dose-dependent antinociceptive action by i.c.v. administration. The ED511 values for tizanidine, clonidine and morphine were increased 2-4-fold 1 or 3 days after spinalization at C5-C6. These results indicate that the antinociceptive activity of tizanidine arises mainly from activity at the supraspinal level, similar to clonidine and morphine, but these drugs act also at the spinal level at high doses.
| Original language | English |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 63 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 02-01-1986 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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Involvement of spinal and supraspinal structures in tizanidine-induced antinociceptive action. / Nabeshima, Toshitaka; Matsuno, Kiyoshi; Kameyama, Tsutomu.
In: Neuroscience Letters, Vol. 63, No. 1, 02.01.1986, p. 1-4.Research output: Contribution to journal › Article
TY - JOUR
T1 - Involvement of spinal and supraspinal structures in tizanidine-induced antinociceptive action
AU - Nabeshima, Toshitaka
AU - Matsuno, Kiyoshi
AU - Kameyama, Tsutomu
PY - 1986/1/2
Y1 - 1986/1/2
N2 - The site of action of tizanidine (5-chloro-4-(2-imidazolin-2-yl-amino)2,1,3-benzothiadiazole) was investigated in a tail-flick test in comparison with clonidine and morphine. Tizanidine and clonidine produced a profound and linear dose-dependent antinociceptive action by i.c.v. administration. The ED511 values for tizanidine, clonidine and morphine were increased 2-4-fold 1 or 3 days after spinalization at C5-C6. These results indicate that the antinociceptive activity of tizanidine arises mainly from activity at the supraspinal level, similar to clonidine and morphine, but these drugs act also at the spinal level at high doses.
AB - The site of action of tizanidine (5-chloro-4-(2-imidazolin-2-yl-amino)2,1,3-benzothiadiazole) was investigated in a tail-flick test in comparison with clonidine and morphine. Tizanidine and clonidine produced a profound and linear dose-dependent antinociceptive action by i.c.v. administration. The ED511 values for tizanidine, clonidine and morphine were increased 2-4-fold 1 or 3 days after spinalization at C5-C6. These results indicate that the antinociceptive activity of tizanidine arises mainly from activity at the supraspinal level, similar to clonidine and morphine, but these drugs act also at the spinal level at high doses.
UR - http://www.scopus.com/inward/record.url?scp=0022637558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022637558&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(86)90002-9
DO - 10.1016/0304-3940(86)90002-9
M3 - Article
C2 - 3951736
AN - SCOPUS:0022637558
VL - 63
SP - 1
EP - 4
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -