TY - JOUR
T1 - Involvement of the cholinergic neuronal system and benzodiazepine receptors in alcohol-induced amnesia
AU - Toshitaka, Nabeshima
AU - Keiko, Tohyama
AU - Sei-ichi, Ishihara
AU - Tsutomu, Kameyama
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1991/3/26
Y1 - 1991/3/26
N2 - We investigated the involvement of the GABAergic and cholinergic neuronal systems and benzodiazepine (BZP) receptors in ethanol-induced amnesia using a passive avoidance task. Pretraining administration of ethanol impaired the passive avoidance response. The BZP agonist chlordiazepoxide potentiated the amnesia, while the GABA antagonists bicuculline and picrotoxin failed to affect it. The acetylcholine esterase inhibitor physostigmine partially attenuated the ethanol-induced amnesia. These results suggest that ethanol-induced amnesia is related to BZP receptors and a dysfunction of the cholinergic neuronal system.
AB - We investigated the involvement of the GABAergic and cholinergic neuronal systems and benzodiazepine (BZP) receptors in ethanol-induced amnesia using a passive avoidance task. Pretraining administration of ethanol impaired the passive avoidance response. The BZP agonist chlordiazepoxide potentiated the amnesia, while the GABA antagonists bicuculline and picrotoxin failed to affect it. The acetylcholine esterase inhibitor physostigmine partially attenuated the ethanol-induced amnesia. These results suggest that ethanol-induced amnesia is related to BZP receptors and a dysfunction of the cholinergic neuronal system.
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U2 - 10.1016/0014-2999(91)90548-5
DO - 10.1016/0014-2999(91)90548-5
M3 - Article
C2 - 1651866
AN - SCOPUS:0026013492
SN - 0014-2999
VL - 195
SP - 285
EP - 289
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -