Involvement of the cholinergic neuronal system and benzodiazepine receptors in alcohol-induced amnesia

Nabeshima Toshitaka; Tohyama Keiko; Ishihara Sei-ichi; Kameyama Tsutomu

doi:10.1016/0014-2999(91)90548-5

Involvement of the cholinergic neuronal system and benzodiazepine receptors in alcohol-induced amnesia

Nabeshima Toshitaka
, Tohyama Keiko
, Ishihara Sei-ichi
, Kameyama Tsutomu

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We investigated the involvement of the GABAergic and cholinergic neuronal systems and benzodiazepine (BZP) receptors in ethanol-induced amnesia using a passive avoidance task. Pretraining administration of ethanol impaired the passive avoidance response. The BZP agonist chlordiazepoxide potentiated the amnesia, while the GABA antagonists bicuculline and picrotoxin failed to affect it. The acetylcholine esterase inhibitor physostigmine partially attenuated the ethanol-induced amnesia. These results suggest that ethanol-induced amnesia is related to BZP receptors and a dysfunction of the cholinergic neuronal system.

Original language	English
Pages (from-to)	285-289
Number of pages	5
Journal	European Journal of Pharmacology
Volume	195
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(91)90548-5
Publication status	Published - 26-03-1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

Access to Document

10.1016/0014-2999(91)90548-5

Cite this

@article{922b31629afc41a3a3b31944d03f302f,

title = "Involvement of the cholinergic neuronal system and benzodiazepine receptors in alcohol-induced amnesia",

abstract = "We investigated the involvement of the GABAergic and cholinergic neuronal systems and benzodiazepine (BZP) receptors in ethanol-induced amnesia using a passive avoidance task. Pretraining administration of ethanol impaired the passive avoidance response. The BZP agonist chlordiazepoxide potentiated the amnesia, while the GABA antagonists bicuculline and picrotoxin failed to affect it. The acetylcholine esterase inhibitor physostigmine partially attenuated the ethanol-induced amnesia. These results suggest that ethanol-induced amnesia is related to BZP receptors and a dysfunction of the cholinergic neuronal system.",

author = "Nabeshima Toshitaka and Tohyama Keiko and Ishihara Sei-ichi and Kameyama Tsutomu",

year = "1991",

month = mar,

day = "26",

doi = "10.1016/0014-2999(91)90548-5",

language = "English",

volume = "195",

pages = "285--289",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Involvement of the cholinergic neuronal system and benzodiazepine receptors in alcohol-induced amnesia

AU - Toshitaka, Nabeshima

AU - Keiko, Tohyama

AU - Sei-ichi, Ishihara

AU - Tsutomu, Kameyama

PY - 1991/3/26

Y1 - 1991/3/26

N2 - We investigated the involvement of the GABAergic and cholinergic neuronal systems and benzodiazepine (BZP) receptors in ethanol-induced amnesia using a passive avoidance task. Pretraining administration of ethanol impaired the passive avoidance response. The BZP agonist chlordiazepoxide potentiated the amnesia, while the GABA antagonists bicuculline and picrotoxin failed to affect it. The acetylcholine esterase inhibitor physostigmine partially attenuated the ethanol-induced amnesia. These results suggest that ethanol-induced amnesia is related to BZP receptors and a dysfunction of the cholinergic neuronal system.

AB - We investigated the involvement of the GABAergic and cholinergic neuronal systems and benzodiazepine (BZP) receptors in ethanol-induced amnesia using a passive avoidance task. Pretraining administration of ethanol impaired the passive avoidance response. The BZP agonist chlordiazepoxide potentiated the amnesia, while the GABA antagonists bicuculline and picrotoxin failed to affect it. The acetylcholine esterase inhibitor physostigmine partially attenuated the ethanol-induced amnesia. These results suggest that ethanol-induced amnesia is related to BZP receptors and a dysfunction of the cholinergic neuronal system.

UR - https://www.scopus.com/pages/publications/0026013492

UR - https://www.scopus.com/pages/publications/0026013492#tab=citedBy

U2 - 10.1016/0014-2999(91)90548-5

DO - 10.1016/0014-2999(91)90548-5

M3 - Article

C2 - 1651866

AN - SCOPUS:0026013492

SN - 0014-2999

VL - 195

SP - 285

EP - 289

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2

ER -

Involvement of the cholinergic neuronal system and benzodiazepine receptors in alcohol-induced amnesia

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this