Involvement of the serotonergic neuronal system in phencyclidine-induced place aversion in rats

Kiyoyuki Kitaichi, Yukihiro Noda, Yoshiaki Miyamoto, Atsushi Numaguchi, Hirokatsu Osawa, Takaaki Hasegawa, Hiroshi Furukawa, Toshitaka Nabeshima

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14 Citations (Scopus)


The possible involvement of the serotonergic neuronal system in aversive motivation produced by phencyclidine [1-(1-phenylcyclohexyl)piperidine; PCP] was investigated using a place-conditioning paradigm in rats. PCP (4 mg/kg, i.p.) produced place aversion in this task as reported previously (Kitaichi K, Noda Y, Hasegawa T, Furukawa H, Nabeshima T. Acute phencyclidine induces aversion, but repeated phencyclidine induces preference in the place conditioning test in rats. Eur J Pharmacol 1996;318:7-9). The blockade of serotonin(2A) (5-HT(2A)) receptors using the antagonist ritanserin (3 and 10 mg/kg, p.o) significantly attenuated this aversive property of PCP whereas lesions of serotonergic neurons using 5,7-dihydroxytryptamine (5,7-DHT, 100 μg/animal, i.c.v.) failed to affect it. Repeated PCP treatment (10 mg/kg, i.p. for 14 days), which is enough to diminish the stereotyped 5-HT(2A) receptor-mediated head-twitch behavior, also decreased the place aversion. These results suggest that the serotonergic neuronal system, specifically the 5-HT(2A) receptor, may play a critical role in producing PCP-induced place aversion.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalBehavioural Brain Research
Issue number1
Publication statusPublished - 08-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience


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