IQGAP1: A key regulator of adhesion and migration

Jun Noritake; Takashi Watanabe; Kazumasa Sato; Shujie Wang; Kozo Kaibuchi

doi:10.1242/jcs.02379

IQGAP1: A key regulator of adhesion and migration

Jun Noritake, Takashi Watanabe, Kazumasa Sato, Shujie Wang, Kozo Kaibuchi

Research output: Contribution to journal › Article › peer-review

313 Citations (Scopus)

Abstract

The dynamic rearrangement of cell-cell adhesion is one of the major physiological events in tissue development and tumor metastasis. Polarized cell migration, another key event, is a tightly regulated process that occurs during tissue development, chemotaxis and wound healing. Rho-family small GTPases, especially Rac1 and Cdc42, play pivotal roles in these processes through one of their effectors, IQGAP1. Recent studies reveal that IQGAP1 regulates cadherin-mediated cell-cell adhesion both positively and negatively. It captures and stabilizes microtubules through the microtubule-binding protein CLIP-170 near the cell cortex, leading to establishment of polarized cell morphology and directional cell migration. Furthermore, Rac1 and Cdc42 link the adenomatous; polyposis coli (APC) protein to actin filaments through IQGAP1 at the leading edge and thereby regulate polarization and directional migration.

Original language	English
Pages (from-to)	2085-2092
Number of pages	8
Journal	Journal of cell science
Volume	118
Issue number	10
DOIs	https://doi.org/10.1242/jcs.02379
Publication status	Published - 15-05-2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1242/jcs.02379

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title = "IQGAP1: A key regulator of adhesion and migration",

abstract = "The dynamic rearrangement of cell-cell adhesion is one of the major physiological events in tissue development and tumor metastasis. Polarized cell migration, another key event, is a tightly regulated process that occurs during tissue development, chemotaxis and wound healing. Rho-family small GTPases, especially Rac1 and Cdc42, play pivotal roles in these processes through one of their effectors, IQGAP1. Recent studies reveal that IQGAP1 regulates cadherin-mediated cell-cell adhesion both positively and negatively. It captures and stabilizes microtubules through the microtubule-binding protein CLIP-170 near the cell cortex, leading to establishment of polarized cell morphology and directional cell migration. Furthermore, Rac1 and Cdc42 link the adenomatous; polyposis coli (APC) protein to actin filaments through IQGAP1 at the leading edge and thereby regulate polarization and directional migration.",

keywords = "APC, CLIP-170, Cadherin, Cdc42, Cell adhesion, Cell polarization, IQGAP1, Rac1, Rho-family GTPases",

author = "Jun Noritake and Takashi Watanabe and Kazumasa Sato and Shujie Wang and Kozo Kaibuchi",

year = "2005",

month = may,

day = "15",

doi = "10.1242/jcs.02379",

language = "English",

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journal = "Journal of cell science",

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TY - JOUR

T1 - IQGAP1

T2 - A key regulator of adhesion and migration

AU - Noritake, Jun

AU - Watanabe, Takashi

AU - Sato, Kazumasa

AU - Wang, Shujie

AU - Kaibuchi, Kozo

PY - 2005/5/15

Y1 - 2005/5/15

N2 - The dynamic rearrangement of cell-cell adhesion is one of the major physiological events in tissue development and tumor metastasis. Polarized cell migration, another key event, is a tightly regulated process that occurs during tissue development, chemotaxis and wound healing. Rho-family small GTPases, especially Rac1 and Cdc42, play pivotal roles in these processes through one of their effectors, IQGAP1. Recent studies reveal that IQGAP1 regulates cadherin-mediated cell-cell adhesion both positively and negatively. It captures and stabilizes microtubules through the microtubule-binding protein CLIP-170 near the cell cortex, leading to establishment of polarized cell morphology and directional cell migration. Furthermore, Rac1 and Cdc42 link the adenomatous; polyposis coli (APC) protein to actin filaments through IQGAP1 at the leading edge and thereby regulate polarization and directional migration.

AB - The dynamic rearrangement of cell-cell adhesion is one of the major physiological events in tissue development and tumor metastasis. Polarized cell migration, another key event, is a tightly regulated process that occurs during tissue development, chemotaxis and wound healing. Rho-family small GTPases, especially Rac1 and Cdc42, play pivotal roles in these processes through one of their effectors, IQGAP1. Recent studies reveal that IQGAP1 regulates cadherin-mediated cell-cell adhesion both positively and negatively. It captures and stabilizes microtubules through the microtubule-binding protein CLIP-170 near the cell cortex, leading to establishment of polarized cell morphology and directional cell migration. Furthermore, Rac1 and Cdc42 link the adenomatous; polyposis coli (APC) protein to actin filaments through IQGAP1 at the leading edge and thereby regulate polarization and directional migration.

KW - APC

KW - CLIP-170

KW - Cadherin

KW - Cdc42

KW - Cell adhesion

KW - Cell polarization

KW - IQGAP1

KW - Rac1

KW - Rho-family GTPases

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DO - 10.1242/jcs.02379

M3 - Article

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AN - SCOPUS:21044443326

SN - 0021-9533

VL - 118

SP - 2085

EP - 2092

JO - Journal of cell science

JF - Journal of cell science

IS - 10

ER -

IQGAP1: A key regulator of adhesion and migration

Abstract

All Science Journal Classification (ASJC) codes

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