IQGAP1: A key regulator of adhesion and migration

Jun Noritake, Takashi Watanabe, Kazumasa Sato, Shujie Wang, Kozo Kaibuchi

Research output: Contribution to journalArticle

261 Citations (Scopus)

Abstract

The dynamic rearrangement of cell-cell adhesion is one of the major physiological events in tissue development and tumor metastasis. Polarized cell migration, another key event, is a tightly regulated process that occurs during tissue development, chemotaxis and wound healing. Rho-family small GTPases, especially Rac1 and Cdc42, play pivotal roles in these processes through one of their effectors, IQGAP1. Recent studies reveal that IQGAP1 regulates cadherin-mediated cell-cell adhesion both positively and negatively. It captures and stabilizes microtubules through the microtubule-binding protein CLIP-170 near the cell cortex, leading to establishment of polarized cell morphology and directional cell migration. Furthermore, Rac1 and Cdc42 link the adenomatous; polyposis coli (APC) protein to actin filaments through IQGAP1 at the leading edge and thereby regulate polarization and directional migration.

Original languageEnglish
Pages (from-to)2085-2092
Number of pages8
JournalJournal of cell science
Volume118
Issue number10
DOIs
Publication statusPublished - 15-05-2005

All Science Journal Classification (ASJC) codes

  • Cell Biology

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