TY - JOUR
T1 - IQGAPS as key regulators of actin-cytoskeleton dynamics
AU - Watanabe, Takashi
AU - Wang, Shujie
AU - Kaibuchi, Kozo
N1 - Publisher Copyright:
© 2015 by Japan Society for Cell Biology.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015/6/6
Y1 - 2015/6/6
N2 - The actin-cytoskeleton plays a critical role in various biological processes, including cell migration, development, tissue remodeling, and memory formation. Both extracellular and intracellular signals regulate reorganization of the actin-cytoskeleton to modulate tissue architecture and cellular morphology in a spatiotemporal manner. Since the discovery that activation of Rho family GTPases induces actin-cytoskeleton reorganization, the mode of action of Rho family GTPases has been extensively studied and individual effectors have been characterized. The actin-binding protein IQGAP1 was identified as an effector of Rac and Cdc42 and is the founding member of the IQGAP family with two additional isoforms. The IQGAP family shows conserved domain organization, and each member displays a specific expression pattern in mammalian tissues. IQGAPs regulate the actin-cytoskeleton alone and with their binding partners, thereby controlling diverse cellular processes, such as cell migration and adhesion. Here, we introduce IQGAPs as an actin-cytoskeleton regulator.
AB - The actin-cytoskeleton plays a critical role in various biological processes, including cell migration, development, tissue remodeling, and memory formation. Both extracellular and intracellular signals regulate reorganization of the actin-cytoskeleton to modulate tissue architecture and cellular morphology in a spatiotemporal manner. Since the discovery that activation of Rho family GTPases induces actin-cytoskeleton reorganization, the mode of action of Rho family GTPases has been extensively studied and individual effectors have been characterized. The actin-binding protein IQGAP1 was identified as an effector of Rac and Cdc42 and is the founding member of the IQGAP family with two additional isoforms. The IQGAP family shows conserved domain organization, and each member displays a specific expression pattern in mammalian tissues. IQGAPs regulate the actin-cytoskeleton alone and with their binding partners, thereby controlling diverse cellular processes, such as cell migration and adhesion. Here, we introduce IQGAPs as an actin-cytoskeleton regulator.
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U2 - 10.1247/csf.15003
DO - 10.1247/csf.15003
M3 - Article
C2 - 26051604
AN - SCOPUS:84937552871
VL - 40
SP - 69
EP - 77
JO - Cell Structure and Function
JF - Cell Structure and Function
SN - 0386-7196
IS - 2
ER -