IRR is involved in glucose-induced endocytosis after insulin secretion

Mami Yamaoka, Takeshi Terabayashi, Tomoki Nishioka, Kozo Kaibuchi, Tomohisa Ishikawa, Toshimasa Ishizaki, Toshihide Kimura

Research output: Contribution to journalArticle

Abstract

Endocytosis after insulin secretion plays a pivotal role in the regulation of insulin secretion in pancreatic β-cells. Our recent study suggested that EPI64, a GTPase activating protein for Rab27a, contributes to the regulation of glucose-induced endocytosis, which is mediated by the GDP-bound form of Rab27a. Here, we identified insulin receptor-related receptor (IRR) as an EPI64-interacting protein. Knockdown of IRR inhibited glucose-induced uptake of transferrin, a marker of endocytosis, translocation of the guanine-nucleotide-exchange factor ARNO to the plasma membrane, and generation of phosphatidylinositol 3,4,5-trisphosphate (PIP3). These results suggest that IRR functions upstream of PIP3 generation and controls endocytosis after insulin secretion.

Original languageEnglish
Pages (from-to)300-304
Number of pages5
JournalJournal of Pharmacological Sciences
Volume140
Issue number3
DOIs
Publication statusPublished - 07-2019

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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    Yamaoka, M., Terabayashi, T., Nishioka, T., Kaibuchi, K., Ishikawa, T., Ishizaki, T., & Kimura, T. (2019). IRR is involved in glucose-induced endocytosis after insulin secretion. Journal of Pharmacological Sciences, 140(3), 300-304. https://doi.org/10.1016/j.jphs.2019.07.002