TY - JOUR
T1 - Irreversible inhibition of metallo-β-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)-propionic acid pentafluorophenyl ester
AU - Kurosaki, Hiromasa
AU - Yamaguchi, Yoshihiro
AU - Higashi, Toshihiro
AU - Soga, Kimitaka
AU - Matsueda, Satoshi
AU - Yumoto, Haruka
AU - Misumi, Shogo
AU - Yamagata, Yuriko
AU - Arakawa, Yoshichika
AU - Goto, Masafumi
PY - 2005/6/20
Y1 - 2005/6/20
N2 - Resistance is futile: Pathogenic bacteria that produce metallo-β- lactamases are recognized as a serious threat because of their resistance to antibiotics. The title compound has now been shown to be an irreversible inhibitor for a metallo-β-lactamase (IMP-1). The X-ray crystallographic structure (see picture) has revealed that the inhibitor binds to IMP-1 with formation of a covalent amide bond with the amino group (Nζ) of Lys 224. (Figure Presented)
AB - Resistance is futile: Pathogenic bacteria that produce metallo-β- lactamases are recognized as a serious threat because of their resistance to antibiotics. The title compound has now been shown to be an irreversible inhibitor for a metallo-β-lactamase (IMP-1). The X-ray crystallographic structure (see picture) has revealed that the inhibitor binds to IMP-1 with formation of a covalent amide bond with the amino group (Nζ) of Lys 224. (Figure Presented)
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U2 - 10.1002/anie.200500835
DO - 10.1002/anie.200500835
M3 - Article
C2 - 15892033
AN - SCOPUS:21244446747
SN - 1433-7851
VL - 44
SP - 3861
EP - 3864
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 25
ER -