Is arteriolar vacuolization a predictor of calcineurin inhibitor nephrotoxicity?

Keiji Horike, Asami Takeda, Yutaka Yamaguchi, Yoshiaki Ogiyama, Yukako Yamauchi, Minako Murata, Takehiko Kawaguchi, Taisei Suzuki, Yasuhiro Otsuka, Daijo Inaguma, Norihiko Goto, Yoshihiko Watarai, Kazuharu Uchida, Kunio Morozumi

Research output: Contribution to journalComment/debate

9 Citations (Scopus)

Abstract

Calcineurin inhibitors (CNI) have been commonly used as pivotal immunosuppressive agents to renal transplant recipients and have contributed significantly to improving short-term allograft survival. However, long-term administration of CNI may cause an adverse effect on kidney function, known as chronic nephrotoxicity. Chronic CNI nephrotoxicity (CNI-NT) shows characteristic histopathological findings that involve arteriolar hyalinosis. Recently, the term alternative arteriolar hyalinosis (aah) is used to discriminate CNI-specific arteriolar hyaline deposition from non-specific arteriolar hyalinosis. We studied whether arteriolar vacuolization represents an early lesion of aah as a predictor of CNI-NT. We retrospectively studied the 79 patients under treatment with a CNI immunosuppressant, who underwent living-related renal transplantation (RTx) from January 2007 to March 2009. We examined serial protocol graft biopsies at oneh, one, six, and 12months after RTx. We classified histological findings into two groups on the basis of aah lesion (with or without aah) in serial biopsies for 12months. Arteriolar vacuolization was more frequently observed in the aah group than in the non-aah group with a significant difference. Arteriolar vacuolization was found even in the one-h biopsy specimens, indicating a non-specific histopathological finding. But in the aah group, arteriolar vacuolization tended to be more frequently observed later on. Aah can be a predictor of CNI-NT.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalClinical Transplantation
Volume25
Issue numberSUPPL. 23
DOIs
Publication statusPublished - 01-07-2011
Externally publishedYes

Fingerprint

Immunosuppressive Agents
Biopsy
Kidney
Hyalin
Calcineurin Inhibitors
Kidney Transplantation
Allografts
Transplants
Therapeutics
Transplant Recipients

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Horike, K., Takeda, A., Yamaguchi, Y., Ogiyama, Y., Yamauchi, Y., Murata, M., ... Morozumi, K. (2011). Is arteriolar vacuolization a predictor of calcineurin inhibitor nephrotoxicity? Clinical Transplantation, 25(SUPPL. 23), 23-27. https://doi.org/10.1111/j.1399-0012.2011.01474.x
Horike, Keiji ; Takeda, Asami ; Yamaguchi, Yutaka ; Ogiyama, Yoshiaki ; Yamauchi, Yukako ; Murata, Minako ; Kawaguchi, Takehiko ; Suzuki, Taisei ; Otsuka, Yasuhiro ; Inaguma, Daijo ; Goto, Norihiko ; Watarai, Yoshihiko ; Uchida, Kazuharu ; Morozumi, Kunio. / Is arteriolar vacuolization a predictor of calcineurin inhibitor nephrotoxicity?. In: Clinical Transplantation. 2011 ; Vol. 25, No. SUPPL. 23. pp. 23-27.
@article{2e3063c10b9d4785ad5fd7620ce2deec,
title = "Is arteriolar vacuolization a predictor of calcineurin inhibitor nephrotoxicity?",
abstract = "Calcineurin inhibitors (CNI) have been commonly used as pivotal immunosuppressive agents to renal transplant recipients and have contributed significantly to improving short-term allograft survival. However, long-term administration of CNI may cause an adverse effect on kidney function, known as chronic nephrotoxicity. Chronic CNI nephrotoxicity (CNI-NT) shows characteristic histopathological findings that involve arteriolar hyalinosis. Recently, the term alternative arteriolar hyalinosis (aah) is used to discriminate CNI-specific arteriolar hyaline deposition from non-specific arteriolar hyalinosis. We studied whether arteriolar vacuolization represents an early lesion of aah as a predictor of CNI-NT. We retrospectively studied the 79 patients under treatment with a CNI immunosuppressant, who underwent living-related renal transplantation (RTx) from January 2007 to March 2009. We examined serial protocol graft biopsies at oneh, one, six, and 12months after RTx. We classified histological findings into two groups on the basis of aah lesion (with or without aah) in serial biopsies for 12months. Arteriolar vacuolization was more frequently observed in the aah group than in the non-aah group with a significant difference. Arteriolar vacuolization was found even in the one-h biopsy specimens, indicating a non-specific histopathological finding. But in the aah group, arteriolar vacuolization tended to be more frequently observed later on. Aah can be a predictor of CNI-NT.",
author = "Keiji Horike and Asami Takeda and Yutaka Yamaguchi and Yoshiaki Ogiyama and Yukako Yamauchi and Minako Murata and Takehiko Kawaguchi and Taisei Suzuki and Yasuhiro Otsuka and Daijo Inaguma and Norihiko Goto and Yoshihiko Watarai and Kazuharu Uchida and Kunio Morozumi",
year = "2011",
month = "7",
day = "1",
doi = "10.1111/j.1399-0012.2011.01474.x",
language = "English",
volume = "25",
pages = "23--27",
journal = "Clinical Transplantation",
issn = "0902-0063",
publisher = "Wiley-Blackwell",
number = "SUPPL. 23",

}

Horike, K, Takeda, A, Yamaguchi, Y, Ogiyama, Y, Yamauchi, Y, Murata, M, Kawaguchi, T, Suzuki, T, Otsuka, Y, Inaguma, D, Goto, N, Watarai, Y, Uchida, K & Morozumi, K 2011, 'Is arteriolar vacuolization a predictor of calcineurin inhibitor nephrotoxicity?', Clinical Transplantation, vol. 25, no. SUPPL. 23, pp. 23-27. https://doi.org/10.1111/j.1399-0012.2011.01474.x

Is arteriolar vacuolization a predictor of calcineurin inhibitor nephrotoxicity? / Horike, Keiji; Takeda, Asami; Yamaguchi, Yutaka; Ogiyama, Yoshiaki; Yamauchi, Yukako; Murata, Minako; Kawaguchi, Takehiko; Suzuki, Taisei; Otsuka, Yasuhiro; Inaguma, Daijo; Goto, Norihiko; Watarai, Yoshihiko; Uchida, Kazuharu; Morozumi, Kunio.

In: Clinical Transplantation, Vol. 25, No. SUPPL. 23, 01.07.2011, p. 23-27.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Is arteriolar vacuolization a predictor of calcineurin inhibitor nephrotoxicity?

AU - Horike, Keiji

AU - Takeda, Asami

AU - Yamaguchi, Yutaka

AU - Ogiyama, Yoshiaki

AU - Yamauchi, Yukako

AU - Murata, Minako

AU - Kawaguchi, Takehiko

AU - Suzuki, Taisei

AU - Otsuka, Yasuhiro

AU - Inaguma, Daijo

AU - Goto, Norihiko

AU - Watarai, Yoshihiko

AU - Uchida, Kazuharu

AU - Morozumi, Kunio

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Calcineurin inhibitors (CNI) have been commonly used as pivotal immunosuppressive agents to renal transplant recipients and have contributed significantly to improving short-term allograft survival. However, long-term administration of CNI may cause an adverse effect on kidney function, known as chronic nephrotoxicity. Chronic CNI nephrotoxicity (CNI-NT) shows characteristic histopathological findings that involve arteriolar hyalinosis. Recently, the term alternative arteriolar hyalinosis (aah) is used to discriminate CNI-specific arteriolar hyaline deposition from non-specific arteriolar hyalinosis. We studied whether arteriolar vacuolization represents an early lesion of aah as a predictor of CNI-NT. We retrospectively studied the 79 patients under treatment with a CNI immunosuppressant, who underwent living-related renal transplantation (RTx) from January 2007 to March 2009. We examined serial protocol graft biopsies at oneh, one, six, and 12months after RTx. We classified histological findings into two groups on the basis of aah lesion (with or without aah) in serial biopsies for 12months. Arteriolar vacuolization was more frequently observed in the aah group than in the non-aah group with a significant difference. Arteriolar vacuolization was found even in the one-h biopsy specimens, indicating a non-specific histopathological finding. But in the aah group, arteriolar vacuolization tended to be more frequently observed later on. Aah can be a predictor of CNI-NT.

AB - Calcineurin inhibitors (CNI) have been commonly used as pivotal immunosuppressive agents to renal transplant recipients and have contributed significantly to improving short-term allograft survival. However, long-term administration of CNI may cause an adverse effect on kidney function, known as chronic nephrotoxicity. Chronic CNI nephrotoxicity (CNI-NT) shows characteristic histopathological findings that involve arteriolar hyalinosis. Recently, the term alternative arteriolar hyalinosis (aah) is used to discriminate CNI-specific arteriolar hyaline deposition from non-specific arteriolar hyalinosis. We studied whether arteriolar vacuolization represents an early lesion of aah as a predictor of CNI-NT. We retrospectively studied the 79 patients under treatment with a CNI immunosuppressant, who underwent living-related renal transplantation (RTx) from January 2007 to March 2009. We examined serial protocol graft biopsies at oneh, one, six, and 12months after RTx. We classified histological findings into two groups on the basis of aah lesion (with or without aah) in serial biopsies for 12months. Arteriolar vacuolization was more frequently observed in the aah group than in the non-aah group with a significant difference. Arteriolar vacuolization was found even in the one-h biopsy specimens, indicating a non-specific histopathological finding. But in the aah group, arteriolar vacuolization tended to be more frequently observed later on. Aah can be a predictor of CNI-NT.

UR - http://www.scopus.com/inward/record.url?scp=79957597088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957597088&partnerID=8YFLogxK

U2 - 10.1111/j.1399-0012.2011.01474.x

DO - 10.1111/j.1399-0012.2011.01474.x

M3 - Comment/debate

VL - 25

SP - 23

EP - 27

JO - Clinical Transplantation

JF - Clinical Transplantation

SN - 0902-0063

IS - SUPPL. 23

ER -

Horike K, Takeda A, Yamaguchi Y, Ogiyama Y, Yamauchi Y, Murata M et al. Is arteriolar vacuolization a predictor of calcineurin inhibitor nephrotoxicity? Clinical Transplantation. 2011 Jul 1;25(SUPPL. 23):23-27. https://doi.org/10.1111/j.1399-0012.2011.01474.x