Is omeprazole or misoprostol superior for improving indomethacin-lnduced delayed maturation of granulation tissue in rat gastric ulcers?

Tomiyasu Arisawa, Masao Harata, Yoshio Kamiya, Tomoyuki Shibata, Mitsuo Nagasaka, Masakatsu Nakamura, Hiroshi Fujita, Shin Hasegawa, Masahiko Nakamura, Tamaki Mizuno, Tomomitsu Tahara, Yoshiji Ohta, Hiroshi Nakano

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background and Aims: Proton pump inhibitors (PPI) and prostaglandin (PG) preparations are believed to both prevent NSAID-induced gastric ulcers and promote the delayed healing of gastric ulcers by NSAIDs, but it remains unclear which of these drugs is superior. The aim of this study was to clarify which achieved better healing of NSAID-induced gastric ulcers, not only with respect to epithelialization but also repair of the submucosal tissues. Methods: We used acetic acid to induce gastric ulcers in rats, and compared the changes between a control group, NSAID group, NSAID+PPI group and NSAID + PG group. After removing the stomach of each animal, an ulcer index was calculated and the collagen content and type III collagen content of granulation tissue were measured. We also studied fibroblast dynamics, including proliferation, collagen synthesis, differentiation into myofibroblasts, and apoptosis. Results: lndomethacin prevented re-epithelialization of the ulcers, interfered with fibroblast function, and also delayed the replacement of type III collagen. Omeprazole promoted epithelialization, but could not fully reverse the influence of indomethacin on granulation tissue maturation. A concomitant dose with misoprostol reversed it completely. Conclusions: From our point of view in this study in the use of experimental ulcers, it was thought that compensation of PG should have priority to gastric acid inhibition in terms of healing of NSAID-induced gastric ulcer.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalDigestion
Volume73
Issue number1
DOIs
Publication statusPublished - 01-04-2006

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Misoprostol
Omeprazole
Granulation Tissue
Non-Steroidal Anti-Inflammatory Agents
Stomach Ulcer
Indomethacin
Ulcer
Prostaglandins
Collagen Type III
Proton Pump Inhibitors
Collagen
Fibroblasts
Re-Epithelialization
Myofibroblasts
Gastric Acid
Acetic Acid
Stomach
Apoptosis
Control Groups
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Arisawa, Tomiyasu ; Harata, Masao ; Kamiya, Yoshio ; Shibata, Tomoyuki ; Nagasaka, Mitsuo ; Nakamura, Masakatsu ; Fujita, Hiroshi ; Hasegawa, Shin ; Nakamura, Masahiko ; Mizuno, Tamaki ; Tahara, Tomomitsu ; Ohta, Yoshiji ; Nakano, Hiroshi. / Is omeprazole or misoprostol superior for improving indomethacin-lnduced delayed maturation of granulation tissue in rat gastric ulcers?. In: Digestion. 2006 ; Vol. 73, No. 1. pp. 32-39.
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title = "Is omeprazole or misoprostol superior for improving indomethacin-lnduced delayed maturation of granulation tissue in rat gastric ulcers?",
abstract = "Background and Aims: Proton pump inhibitors (PPI) and prostaglandin (PG) preparations are believed to both prevent NSAID-induced gastric ulcers and promote the delayed healing of gastric ulcers by NSAIDs, but it remains unclear which of these drugs is superior. The aim of this study was to clarify which achieved better healing of NSAID-induced gastric ulcers, not only with respect to epithelialization but also repair of the submucosal tissues. Methods: We used acetic acid to induce gastric ulcers in rats, and compared the changes between a control group, NSAID group, NSAID+PPI group and NSAID + PG group. After removing the stomach of each animal, an ulcer index was calculated and the collagen content and type III collagen content of granulation tissue were measured. We also studied fibroblast dynamics, including proliferation, collagen synthesis, differentiation into myofibroblasts, and apoptosis. Results: lndomethacin prevented re-epithelialization of the ulcers, interfered with fibroblast function, and also delayed the replacement of type III collagen. Omeprazole promoted epithelialization, but could not fully reverse the influence of indomethacin on granulation tissue maturation. A concomitant dose with misoprostol reversed it completely. Conclusions: From our point of view in this study in the use of experimental ulcers, it was thought that compensation of PG should have priority to gastric acid inhibition in terms of healing of NSAID-induced gastric ulcer.",
author = "Tomiyasu Arisawa and Masao Harata and Yoshio Kamiya and Tomoyuki Shibata and Mitsuo Nagasaka and Masakatsu Nakamura and Hiroshi Fujita and Shin Hasegawa and Masahiko Nakamura and Tamaki Mizuno and Tomomitsu Tahara and Yoshiji Ohta and Hiroshi Nakano",
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Arisawa, T, Harata, M, Kamiya, Y, Shibata, T, Nagasaka, M, Nakamura, M, Fujita, H, Hasegawa, S, Nakamura, M, Mizuno, T, Tahara, T, Ohta, Y & Nakano, H 2006, 'Is omeprazole or misoprostol superior for improving indomethacin-lnduced delayed maturation of granulation tissue in rat gastric ulcers?', Digestion, vol. 73, no. 1, pp. 32-39. https://doi.org/10.1159/000092012

Is omeprazole or misoprostol superior for improving indomethacin-lnduced delayed maturation of granulation tissue in rat gastric ulcers? / Arisawa, Tomiyasu; Harata, Masao; Kamiya, Yoshio; Shibata, Tomoyuki; Nagasaka, Mitsuo; Nakamura, Masakatsu; Fujita, Hiroshi; Hasegawa, Shin; Nakamura, Masahiko; Mizuno, Tamaki; Tahara, Tomomitsu; Ohta, Yoshiji; Nakano, Hiroshi.

In: Digestion, Vol. 73, No. 1, 01.04.2006, p. 32-39.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Is omeprazole or misoprostol superior for improving indomethacin-lnduced delayed maturation of granulation tissue in rat gastric ulcers?

AU - Arisawa, Tomiyasu

AU - Harata, Masao

AU - Kamiya, Yoshio

AU - Shibata, Tomoyuki

AU - Nagasaka, Mitsuo

AU - Nakamura, Masakatsu

AU - Fujita, Hiroshi

AU - Hasegawa, Shin

AU - Nakamura, Masahiko

AU - Mizuno, Tamaki

AU - Tahara, Tomomitsu

AU - Ohta, Yoshiji

AU - Nakano, Hiroshi

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Background and Aims: Proton pump inhibitors (PPI) and prostaglandin (PG) preparations are believed to both prevent NSAID-induced gastric ulcers and promote the delayed healing of gastric ulcers by NSAIDs, but it remains unclear which of these drugs is superior. The aim of this study was to clarify which achieved better healing of NSAID-induced gastric ulcers, not only with respect to epithelialization but also repair of the submucosal tissues. Methods: We used acetic acid to induce gastric ulcers in rats, and compared the changes between a control group, NSAID group, NSAID+PPI group and NSAID + PG group. After removing the stomach of each animal, an ulcer index was calculated and the collagen content and type III collagen content of granulation tissue were measured. We also studied fibroblast dynamics, including proliferation, collagen synthesis, differentiation into myofibroblasts, and apoptosis. Results: lndomethacin prevented re-epithelialization of the ulcers, interfered with fibroblast function, and also delayed the replacement of type III collagen. Omeprazole promoted epithelialization, but could not fully reverse the influence of indomethacin on granulation tissue maturation. A concomitant dose with misoprostol reversed it completely. Conclusions: From our point of view in this study in the use of experimental ulcers, it was thought that compensation of PG should have priority to gastric acid inhibition in terms of healing of NSAID-induced gastric ulcer.

AB - Background and Aims: Proton pump inhibitors (PPI) and prostaglandin (PG) preparations are believed to both prevent NSAID-induced gastric ulcers and promote the delayed healing of gastric ulcers by NSAIDs, but it remains unclear which of these drugs is superior. The aim of this study was to clarify which achieved better healing of NSAID-induced gastric ulcers, not only with respect to epithelialization but also repair of the submucosal tissues. Methods: We used acetic acid to induce gastric ulcers in rats, and compared the changes between a control group, NSAID group, NSAID+PPI group and NSAID + PG group. After removing the stomach of each animal, an ulcer index was calculated and the collagen content and type III collagen content of granulation tissue were measured. We also studied fibroblast dynamics, including proliferation, collagen synthesis, differentiation into myofibroblasts, and apoptosis. Results: lndomethacin prevented re-epithelialization of the ulcers, interfered with fibroblast function, and also delayed the replacement of type III collagen. Omeprazole promoted epithelialization, but could not fully reverse the influence of indomethacin on granulation tissue maturation. A concomitant dose with misoprostol reversed it completely. Conclusions: From our point of view in this study in the use of experimental ulcers, it was thought that compensation of PG should have priority to gastric acid inhibition in terms of healing of NSAID-induced gastric ulcer.

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