TY - JOUR
T1 - Is the association between healthy lifestyle behaviors and cardiovascular mortality modified by overweight status? The Japan collaborative cohort study
AU - Eguchi, Eri
AU - Iso, Hiroyasu
AU - Tanabe, Naohito
AU - Yatsuya, Hiroshi
AU - Tamakoshi, Akiko
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan (Monbusho) : 61010076 , 62010074 , 63010074 , 1010068 , 2151065 , 3151064 , 4151063 , 5151069 , 6279102 , 11181101 , 17015022 , 18014011 , 20014026 and 20390156 and the Comprehensive Research on Life-Style Related Diseases including Cardiovascular Diseases and Diabetes Mellitus : H23-Junkankitou [Seishuu]-Ippan-005 .
PY - 2014/5
Y1 - 2014/5
N2 - Objective: To examine the modifying effects of overweight status on the association of healthy lifestyle behaviors with cardiovascular mortality in the Japanese population. Methods: A community-based, prospective cohort of 18,730 men and 24,216 women aged 40-79. years without a history of cardiovascular disease (CVD) or cancer at baseline (1988-1990) was followed until 2009. Healthy lifestyle behaviors included intake of fruits, fish, and milk; exercise; avoidance of smoking; moderate alcohol intake; and moderate sleep duration. Results: During the median of 19.3. years of follow-up, there were 2412 deaths from total CVD. Inverse associations between healthy lifestyle scores and mortality from stroke, total CVD, and coronary heart disease (CHD) were observed for non-overweight and overweight (body mass index ≥. 25. kg/m2) individuals, although the association was weaker for overweight individuals. The multivariable hazard ratios (HRs, 95% confidence interval) of mortality from total CVD for the highest (6-7) versus the lowest (0-2) scores were 0.44 (0.37-0.54) for non-overweight and 0.56 (0.39-0.81) for overweight individuals. Especially for CHD mortality, such association was more evident for non-overweight compared to that for overweight individuals. Conclusions: Our findings suggest that lifestyle modification may be beneficial in the prevention of cardiovascular mortality for persons who are and are not overweight.
AB - Objective: To examine the modifying effects of overweight status on the association of healthy lifestyle behaviors with cardiovascular mortality in the Japanese population. Methods: A community-based, prospective cohort of 18,730 men and 24,216 women aged 40-79. years without a history of cardiovascular disease (CVD) or cancer at baseline (1988-1990) was followed until 2009. Healthy lifestyle behaviors included intake of fruits, fish, and milk; exercise; avoidance of smoking; moderate alcohol intake; and moderate sleep duration. Results: During the median of 19.3. years of follow-up, there were 2412 deaths from total CVD. Inverse associations between healthy lifestyle scores and mortality from stroke, total CVD, and coronary heart disease (CHD) were observed for non-overweight and overweight (body mass index ≥. 25. kg/m2) individuals, although the association was weaker for overweight individuals. The multivariable hazard ratios (HRs, 95% confidence interval) of mortality from total CVD for the highest (6-7) versus the lowest (0-2) scores were 0.44 (0.37-0.54) for non-overweight and 0.56 (0.39-0.81) for overweight individuals. Especially for CHD mortality, such association was more evident for non-overweight compared to that for overweight individuals. Conclusions: Our findings suggest that lifestyle modification may be beneficial in the prevention of cardiovascular mortality for persons who are and are not overweight.
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U2 - 10.1016/j.ypmed.2013.12.004
DO - 10.1016/j.ypmed.2013.12.004
M3 - Article
C2 - 24491467
AN - SCOPUS:84895752917
SN - 0091-7435
VL - 62
SP - 142
EP - 147
JO - Preventive Medicine
JF - Preventive Medicine
ER -
