Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary?

Hiroaki Kajiyama, Kiyosumi Shibata, Shiro Suzuki, Kazuhiko Ino, Eiko Yamamoto, Kimio Mizuno, Katsumi Sakakibara, Katsuji Matsuzawa, Akihiro Takeda, Yoshito Kinoshita, Michiyasu Kawai, Tetsuro Nagasaka, Akihiro Nawa, Fumitaka Kikkawa

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Background: In epithelial ovarian cancer (EOC), fertility-sparing surgery (FSS) has mainly been chosen for stage IA disease. The purpose of this study was to clarify the clinical outcome of patients with clear-cell carcinoma of the ovary (CCC) who would usually undergo radical surgery. Cases: After a central pathological review and search of the medical records from multiple institutions between 1988 and 2005, a total of 10 CCC patients treated with FSS were retrospectively evaluated in the current study. The mean age was 35.9 years (range: 32-39 years). The median follow-up time was 35.4 months (range: 21.7-153.2 months). The stage was IA in 4 patients, and IC in 6 patients {IC(b) in 5 patients, and IC(2) in one}. Nine patients received adjuvant chemotherapy. Nine patients were alive and one patient with stage IC(2) died of the disease at a follow-up time of 36.8 months. Five pregnancies were observed in 4 patients. Conclusions: Although there is no worldwide criterion for FSS in CCC patients at present, it seems that, in selected patients, this surgical approach could be adopted. This should be investigated by additional studies in a larger series.

Original languageEnglish
Pages (from-to)523-526
Number of pages4
JournalGynecologic oncology
Issue number3
Publication statusPublished - 12-2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology


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