Ischemic tolerance in the cochlea

Shoichiro Takeda, Ryuji Hata, Fang Cao, Tadashi Yoshida, Nobuhiro Hakuba, Naohito Hato, Kiyofumi Gyo

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Abstract

Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single ischemia group and double ischemia group. In the single ischemia group, animals were subjected to lethal cochlear ischemia for 15 min. In the double ischemia group, animals were subjected to sublethal cochlear ischemia for 2 min at 2 days before lethal ischemia for 15 min. Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea.

Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalNeuroscience Letters
Volume462
Issue number3
DOIs
Publication statusPublished - 25-09-2009

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Takeda, S., Hata, R., Cao, F., Yoshida, T., Hakuba, N., Hato, N., & Gyo, K. (2009). Ischemic tolerance in the cochlea. Neuroscience Letters, 462(3), 263-266. https://doi.org/10.1016/j.neulet.2009.07.019