Ischemic tolerance in the cochlea

Shoichiro Takeda; Ryuji Hata; Fang Cao; Tadashi Yoshida; Nobuhiro Hakuba; Naohito Hato; Kiyofumi Gyo

doi:10.1016/j.neulet.2009.07.019

Ischemic tolerance in the cochlea

Shoichiro Takeda
, Ryuji Hata
, Fang Cao
, Tadashi Yoshida
, Nobuhiro Hakuba
, Naohito Hato
, Kiyofumi Gyo

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single ischemia group and double ischemia group. In the single ischemia group, animals were subjected to lethal cochlear ischemia for 15 min. In the double ischemia group, animals were subjected to sublethal cochlear ischemia for 2 min at 2 days before lethal ischemia for 15 min. Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea.

Original language	English
Pages (from-to)	263-266
Number of pages	4
Journal	Neuroscience Letters
Volume	462
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2009.07.019
Publication status	Published - 25-09-2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neulet.2009.07.019

Cite this

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title = "Ischemic tolerance in the cochlea",

abstract = "Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single ischemia group and double ischemia group. In the single ischemia group, animals were subjected to lethal cochlear ischemia for 15 min. In the double ischemia group, animals were subjected to sublethal cochlear ischemia for 2 min at 2 days before lethal ischemia for 15 min. Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea.",

author = "Shoichiro Takeda and Ryuji Hata and Fang Cao and Tadashi Yoshida and Nobuhiro Hakuba and Naohito Hato and Kiyofumi Gyo",

note = "Funding Information: The present study was supported in part by Grant-in-Aid for Young Scientists (B) (no. 20791199), and Grant-in-Aid for Scientific Research (B) (no. 20390442), Ministry of Education, Science, Sports and Culture, Japan.",

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doi = "10.1016/j.neulet.2009.07.019",

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T1 - Ischemic tolerance in the cochlea

AU - Takeda, Shoichiro

AU - Hata, Ryuji

AU - Cao, Fang

AU - Yoshida, Tadashi

AU - Hakuba, Nobuhiro

AU - Hato, Naohito

AU - Gyo, Kiyofumi

N1 - Funding Information: The present study was supported in part by Grant-in-Aid for Young Scientists (B) (no. 20791199), and Grant-in-Aid for Scientific Research (B) (no. 20390442), Ministry of Education, Science, Sports and Culture, Japan.

PY - 2009/9/25

Y1 - 2009/9/25

N2 - Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single ischemia group and double ischemia group. In the single ischemia group, animals were subjected to lethal cochlear ischemia for 15 min. In the double ischemia group, animals were subjected to sublethal cochlear ischemia for 2 min at 2 days before lethal ischemia for 15 min. Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea.

AB - Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single ischemia group and double ischemia group. In the single ischemia group, animals were subjected to lethal cochlear ischemia for 15 min. In the double ischemia group, animals were subjected to sublethal cochlear ischemia for 2 min at 2 days before lethal ischemia for 15 min. Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea.

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DO - 10.1016/j.neulet.2009.07.019

M3 - Article

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VL - 462

SP - 263

EP - 266

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Ischemic tolerance in the cochlea

Abstract

All Science Journal Classification (ASJC) codes

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