Isolation and characterization of 2-hydroxy-9,10-anthraquinone from Streptomyces olivochromogenes (ERINLG-261) with antimicrobial and antiproliferative properties

Chandrasekar Balachandran, Veeramuthu Duraipandiyan, Yuvaraj Arun, Balachandran Sangeetha, Nobuhiko Emi, Naif Abdullah Al-Dhabi, Savarimuthu Ignacimuthu, Yoko Inaguma, Akinao Okamoto, Paramasivan T. Perumal

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Currently Streptomyces is one of the most important antibiotic producing microorganisms against several diseases. In the present study Streptomyces olivochromogenes ERINLG-261 was isolated from the soil samples of the Mudumalai hills, Western Ghats, India. Morphological, physiological, biochemical and 16S rRNA studies strongly suggested that this isolate belonged to the genus Streptomyces. ERINLG-261 showed good antimicrobial activity against different bacteria and fungi in Micromonospora fermentation medium. The active ethyl acetate extract was packed in column chromatography over silica gel which led to the isolation of 2-hydroxy-9,10-anthraquinone as the active principle. The isolated compound showed good antimicrobial activity against tested bacteria and fungi in minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) studies. The compound showed moderatein vitro antiproliferative activity against A549 and COLO320 cells. The compound was subjected to molecular docking studies for the inhibition of Topoisomerase, TtgR and Beta-lactamase enzymes which are targets for antimicrobials. Docking results of the compound showed low docking energy with these enzymes indicating its usefulness as antimicrobial agent. This is the first report of antimicrobial and antiproliferative activity of 2-hydroxy-9,10-anthraquinone isolated from Streptomyces olivochromogenes along with molecular docking studies.

Original languageEnglish
Pages (from-to)285-295
Number of pages11
JournalBrazilian Journal of Pharmacognosy
Volume26
Issue number3
DOIs
Publication statusPublished - 01-05-2016

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Streptomyces
Fungi
Micromonospora
Bacteria
Silica Gel
Microbial Sensitivity Tests
Enzymes
beta-Lactamases
Anti-Infective Agents
Fermentation
Chromatography
India
Soil
Anti-Bacterial Agents
9,10-anthraquinone

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Balachandran, Chandrasekar ; Duraipandiyan, Veeramuthu ; Arun, Yuvaraj ; Sangeetha, Balachandran ; Emi, Nobuhiko ; Al-Dhabi, Naif Abdullah ; Ignacimuthu, Savarimuthu ; Inaguma, Yoko ; Okamoto, Akinao ; Perumal, Paramasivan T. / Isolation and characterization of 2-hydroxy-9,10-anthraquinone from Streptomyces olivochromogenes (ERINLG-261) with antimicrobial and antiproliferative properties. In: Brazilian Journal of Pharmacognosy. 2016 ; Vol. 26, No. 3. pp. 285-295.
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Isolation and characterization of 2-hydroxy-9,10-anthraquinone from Streptomyces olivochromogenes (ERINLG-261) with antimicrobial and antiproliferative properties. / Balachandran, Chandrasekar; Duraipandiyan, Veeramuthu; Arun, Yuvaraj; Sangeetha, Balachandran; Emi, Nobuhiko; Al-Dhabi, Naif Abdullah; Ignacimuthu, Savarimuthu; Inaguma, Yoko; Okamoto, Akinao; Perumal, Paramasivan T.

In: Brazilian Journal of Pharmacognosy, Vol. 26, No. 3, 01.05.2016, p. 285-295.

Research output: Contribution to journalArticle

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AU - Balachandran, Chandrasekar

AU - Duraipandiyan, Veeramuthu

AU - Arun, Yuvaraj

AU - Sangeetha, Balachandran

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AU - Al-Dhabi, Naif Abdullah

AU - Ignacimuthu, Savarimuthu

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AU - Okamoto, Akinao

AU - Perumal, Paramasivan T.

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