Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

T. Nomura, M. Ohtsuki, S. Matsui, C. Sumi-Ichinose, H. Nomura, Y. Hagino, K. Iwase, H. Ichinose, K. Fujita, T. Nagatsu

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Abstract

Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the present study, we first isolated a full-length cDNA clone encoding human GCH I type 1 from human pheochromocytoma cDNA library. The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single niRNA species of 4.0kb in human pheochromocytoma tissue.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalJournal of Neural Transmission
Volume101
Issue number1-3
DOIs
Publication statusPublished - 01-02-1995

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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    Nomura, T., Ohtsuki, M., Matsui, S., Sumi-Ichinose, C., Nomura, H., Hagino, Y., Iwase, K., Ichinose, H., Fujita, K., & Nagatsu, T. (1995). Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma. Journal of Neural Transmission, 101(1-3), 237-242. https://doi.org/10.1007/BF01271561