Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

T. Nomura; M. Ohtsuki; S. Matsui; C. Sumi-Ichinose; H. Nomura; Y. Hagino; K. Iwase; H. Ichinose; K. Fujita; T. Nagatsu

doi:10.1007/BF01271561

Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

T. Nomura, M. Ohtsuki, S. Matsui, C. Sumi-Ichinose, H. Nomura, Y. Hagino, K. Iwase, H. Ichinose, K. Fujita, T. Nagatsu

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13 Citations (Scopus)

Abstract

Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the present study, we first isolated a full-length cDNA clone encoding human GCH I type 1 from human pheochromocytoma cDNA library. The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single niRNA species of 4.0kb in human pheochromocytoma tissue.

Original language	English
Pages (from-to)	237-242
Number of pages	6
Journal	Journal of Neural Transmission
Volume	101
Issue number	1-3
DOIs	https://doi.org/10.1007/BF01271561
Publication status	Published - 02-1995

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF01271561

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title = "Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma",

abstract = "Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the present study, we first isolated a full-length cDNA clone encoding human GCH I type 1 from human pheochromocytoma cDNA library. The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single niRNA species of 4.0kb in human pheochromocytoma tissue.",

keywords = "(Human), GTP cyclohydrolase I, cDNA, mRNA, pheochromocytoma, tetrahydrobiopterin",

author = "T. Nomura and M. Ohtsuki and S. Matsui and C. Sumi-Ichinose and H. Nomura and Y. Hagino and K. Iwase and H. Ichinose and K. Fujita and T. Nagatsu",

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doi = "10.1007/BF01271561",

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T1 - Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

AU - Nomura, T.

AU - Ohtsuki, M.

AU - Matsui, S.

AU - Sumi-Ichinose, C.

AU - Nomura, H.

AU - Hagino, Y.

AU - Iwase, K.

AU - Ichinose, H.

AU - Fujita, K.

AU - Nagatsu, T.

PY - 1995/2

Y1 - 1995/2

N2 - Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the present study, we first isolated a full-length cDNA clone encoding human GCH I type 1 from human pheochromocytoma cDNA library. The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single niRNA species of 4.0kb in human pheochromocytoma tissue.

AB - Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the present study, we first isolated a full-length cDNA clone encoding human GCH I type 1 from human pheochromocytoma cDNA library. The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single niRNA species of 4.0kb in human pheochromocytoma tissue.

KW - (Human)

KW - GTP cyclohydrolase I

KW - cDNA

KW - mRNA

KW - pheochromocytoma

KW - tetrahydrobiopterin

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ER -

Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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