Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

T. Nomura; M. Ohtsuki; S. Matsui; C. Sumi-Ichinose; H. Nomura; Y. Hagino; K. Iwase; H. Ichinose; K. Fujita; T. Nagatsu

doi:10.1007/BF01271561

Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

T. Nomura
, M. Ohtsuki
, S. Matsui
, C. Sumi-Ichinose
, H. Nomura
, Y. Hagino
, K. Iwase
, H. Ichinose
, K. Fujita
, T. Nagatsu

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the present study, we first isolated a full-length cDNA clone encoding human GCH I type 1 from human pheochromocytoma cDNA library. The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single niRNA species of 4.0kb in human pheochromocytoma tissue.

Original language	English
Pages (from-to)	237-242
Number of pages	6
Journal	Journal of Neural Transmission
Volume	101
Issue number	1-3
DOIs	https://doi.org/10.1007/BF01271561
Publication status	Published - 02-1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF01271561

Cite this

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title = "Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma",

abstract = "Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the present study, we first isolated a full-length cDNA clone encoding human GCH I type 1 from human pheochromocytoma cDNA library. The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single niRNA species of 4.0kb in human pheochromocytoma tissue.",

keywords = "(Human), GTP cyclohydrolase I, cDNA, mRNA, pheochromocytoma, tetrahydrobiopterin",

author = "T. Nomura and M. Ohtsuki and S. Matsui and C. Sumi-Ichinose and H. Nomura and Y. Hagino and K. Iwase and H. Ichinose and K. Fujita and T. Nagatsu",

year = "1995",

month = feb,

doi = "10.1007/BF01271561",

language = "English",

volume = "101",

pages = "237--242",

journal = "Journal of Neural Transmission",

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publisher = "Springer Verlag",

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TY - JOUR

T1 - Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

AU - Nomura, T.

AU - Ohtsuki, M.

AU - Matsui, S.

AU - Sumi-Ichinose, C.

AU - Nomura, H.

AU - Hagino, Y.

AU - Iwase, K.

AU - Ichinose, H.

AU - Fujita, K.

AU - Nagatsu, T.

PY - 1995/2

Y1 - 1995/2

N2 - Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the present study, we first isolated a full-length cDNA clone encoding human GCH I type 1 from human pheochromocytoma cDNA library. The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single niRNA species of 4.0kb in human pheochromocytoma tissue.

AB - Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the present study, we first isolated a full-length cDNA clone encoding human GCH I type 1 from human pheochromocytoma cDNA library. The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single niRNA species of 4.0kb in human pheochromocytoma tissue.

KW - (Human)

KW - GTP cyclohydrolase I

KW - cDNA

KW - mRNA

KW - pheochromocytoma

KW - tetrahydrobiopterin

UR - https://www.scopus.com/pages/publications/0029111723

UR - https://www.scopus.com/pages/publications/0029111723#tab=citedBy

U2 - 10.1007/BF01271561

DO - 10.1007/BF01271561

M3 - Article

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AN - SCOPUS:0029111723

SN - 0300-9564

VL - 101

SP - 237

EP - 242

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 1-3

ER -

Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma

Abstract

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UN SDGs

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