Isolation of a human monoclonal antibody with strong neutralizing activity against diphtheria toxin

Mai Kakita, Tsuyoshi Takahashi, Takako Komiya, Yoshitaka Iba, Takao Tsuji, Yoshikazu Kurosawa, Motohide Takahashi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity (Kd) of 3.01 nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73,600 IU/g. This could be used as a therapeutic drug against DT in place of the traditional equine sera.

Original languageEnglish
Pages (from-to)3682-3683
Number of pages2
JournalInfection and Immunity
Volume74
Issue number6
DOIs
Publication statusPublished - 06-2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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