TY - JOUR
T1 - Isolation of group a streptococci with reduced in vitro β-lactam susceptibility harboring amino acid substitutions in penicillin-binding proteins in Japan
AU - Ikeda, Tsubasa
AU - Suzuki, Rihito
AU - Jin, Wanchun
AU - Wachino, Jun Ichi
AU - Arakawa, Yoshichika
AU - Kimura, Kouji
N1 - Publisher Copyright:
Copyright © 2021 American Society for Microbiology. All Rights Reserved.
PY - 2021/12
Y1 - 2021/12
N2 - Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.
AB - Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.
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U2 - 10.1128/AAC.01482-21
DO - 10.1128/AAC.01482-21
M3 - Article
C2 - 34606335
AN - SCOPUS:85119339995
SN - 0066-4804
VL - 65
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 12
M1 - e01482-21
ER -
