Isolation of group a streptococci with reduced in vitro β-lactam susceptibility harboring amino acid substitutions in penicillin-binding proteins in Japan

Tsubasa Ikeda; Rihito Suzuki; Wanchun Jin; Jun Ichi Wachino; Yoshichika Arakawa; Kouji Kimura

doi:10.1128/AAC.01482-21

Isolation of group a streptococci with reduced in vitro β-lactam susceptibility harboring amino acid substitutions in penicillin-binding proteins in Japan

Tsubasa Ikeda
, Rihito Suzuki
, Wanchun Jin
, Jun Ichi Wachino
, Yoshichika Arakawa
, Kouji Kimura

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.

Original language	English
Article number	e01482-21
Journal	Antimicrobial agents and chemotherapy
Volume	65
Issue number	12
DOIs	https://doi.org/10.1128/AAC.01482-21
Publication status	Published - 12-2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01482-21

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title = "Isolation of group a streptococci with reduced in vitro β-lactam susceptibility harboring amino acid substitutions in penicillin-binding proteins in Japan",

abstract = "Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.",

keywords = "Antibiotic resistance, Group A streptococcus, Penicillin-binding protein, Streptococcus pyogenes, β-lactam",

author = "Tsubasa Ikeda and Rihito Suzuki and Wanchun Jin and Wachino, \{Jun Ichi\} and Yoshichika Arakawa and Kouji Kimura",

year = "2021",

month = dec,

doi = "10.1128/AAC.01482-21",

language = "English",

volume = "65",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Isolation of group a streptococci with reduced in vitro β-lactam susceptibility harboring amino acid substitutions in penicillin-binding proteins in Japan

AU - Ikeda, Tsubasa

AU - Suzuki, Rihito

AU - Jin, Wanchun

AU - Wachino, Jun Ichi

AU - Arakawa, Yoshichika

AU - Kimura, Kouji

PY - 2021/12

Y1 - 2021/12

N2 - Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.

AB - Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.

KW - Antibiotic resistance

KW - Group A streptococcus

KW - Penicillin-binding protein

KW - Streptococcus pyogenes

KW - β-lactam

UR - https://www.scopus.com/pages/publications/85119339995

UR - https://www.scopus.com/pages/publications/85119339995#tab=citedBy

U2 - 10.1128/AAC.01482-21

DO - 10.1128/AAC.01482-21

M3 - Article

C2 - 34606335

AN - SCOPUS:85119339995

SN - 0066-4804

VL - 65

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 12

M1 - e01482-21

ER -

Isolation of group a streptococci with reduced in vitro β-lactam susceptibility harboring amino acid substitutions in penicillin-binding proteins in Japan

Abstract

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