TY - JOUR
T1 - Iterative reconstruction for quantitative computed tomography analysis of emphysema
T2 - Consistent results using different tube currents
AU - Yamashiro, Tsuneo
AU - Miyara, Tetsuhiro
AU - Honda, Osamu
AU - Tomiyama, Noriyuki
AU - Ohno, Yoshiharu
AU - Moma, Satoshi
AU - Murayama, Sadayuki
N1 - Publisher Copyright:
© 2015 Yamashiro et al.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2015/2/11
Y1 - 2015/2/11
N2 - Purpose: To assess the advantages of iterative reconstruction for quantitative computed tomography (CT) analysis of pulmonary emphysema. Materials and methods: Twenty-two patients with pulmonary emphysema underwent chest CT imaging using identical scanners with three different tube currents: 240, 120, and 60 mA. Scan data were converted to CT images using Adaptive Iterative Dose Reduction using Three Dimensional Processing (AIDR3D) and a conventional filtered-back projection mode. Thus, six scans with and without AIDR3D were generated per patient. All other scanning and reconstruction settings were fixed. The percent low attenuation area (LAA%; < –950 Hounsfield units) and the lung density 15th percentile were automatically measured using a commercial workstation. Comparisons of LAA% and 15th percentile results between scans with and without using AIDR3D were made by Wilcoxon signed-rank tests. Associations between body weight and measurement errors among these scans were evaluated by Spearman rank correlation analysis. Results: Overall, scan series without AIDR3D had higher LAA% and lower 15th percentile values than those with AIDR3D at each tube current (P<0.0001). For scan series without AIDR3D, lower tube currents resulted in higher LAA% values and lower 15th percentiles. The extent of emphysema was significantly different between each pair among scans when not using AIDR3D (LAA%, P<0.0001; 15th percentile, P<0.01), but was not significantly different between each pair among scans when using AIDR3D. On scans without using AIDR3D, measurement errors between different tube current settings were significantly correlated with patients’ body weights (P<0.05), whereas these errors between scans when using AIDR3D were insignificantly or minimally correlated with body weight. Conclusion: The extent of emphysema was more consistent across different tube currents when CT scans were converted to CT images using AIDR3D than using a conventional filtered-back projection method.
AB - Purpose: To assess the advantages of iterative reconstruction for quantitative computed tomography (CT) analysis of pulmonary emphysema. Materials and methods: Twenty-two patients with pulmonary emphysema underwent chest CT imaging using identical scanners with three different tube currents: 240, 120, and 60 mA. Scan data were converted to CT images using Adaptive Iterative Dose Reduction using Three Dimensional Processing (AIDR3D) and a conventional filtered-back projection mode. Thus, six scans with and without AIDR3D were generated per patient. All other scanning and reconstruction settings were fixed. The percent low attenuation area (LAA%; < –950 Hounsfield units) and the lung density 15th percentile were automatically measured using a commercial workstation. Comparisons of LAA% and 15th percentile results between scans with and without using AIDR3D were made by Wilcoxon signed-rank tests. Associations between body weight and measurement errors among these scans were evaluated by Spearman rank correlation analysis. Results: Overall, scan series without AIDR3D had higher LAA% and lower 15th percentile values than those with AIDR3D at each tube current (P<0.0001). For scan series without AIDR3D, lower tube currents resulted in higher LAA% values and lower 15th percentiles. The extent of emphysema was significantly different between each pair among scans when not using AIDR3D (LAA%, P<0.0001; 15th percentile, P<0.01), but was not significantly different between each pair among scans when using AIDR3D. On scans without using AIDR3D, measurement errors between different tube current settings were significantly correlated with patients’ body weights (P<0.05), whereas these errors between scans when using AIDR3D were insignificantly or minimally correlated with body weight. Conclusion: The extent of emphysema was more consistent across different tube currents when CT scans were converted to CT images using AIDR3D than using a conventional filtered-back projection method.
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U2 - 10.2147/COPD.S74810
DO - 10.2147/COPD.S74810
M3 - Article
C2 - 25709426
AN - SCOPUS:84922930061
VL - 10
SP - 321
EP - 327
JO - International Journal of COPD
JF - International Journal of COPD
SN - 1176-9106
ER -