Japanese cedar pollen-based subcutaneous immunotherapy decreases tomato fruit-specific basophil activation

Chisato Inuo, Yasuto Kondo, Kenichi Tanaka, Yoichi Nakajima, Takayasu Nomura, Hitoshi Ando, Satoko Suzuki, Ikuya Tsuge, Tetsushi Yoshikawa, Atsuo Urisu

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Abstract

Background: Some patients with Japanese cedar pollen (JCP)-induced allergic rhinitis develop pollen-food allergy syndrome (PFAS) as a reaction to tomato fruit. Pollen allergen-specific subcutaneous immunotherapy (SCIT) is reportedly beneficial for some associated food allergies; however, the reported changes in food allergen-specific immunoglobulin (Ig)E and IgG 4 levels are inconsistent. Here, we investigated immunologic reactivity to tomato fruit after JCP-based SCIT. Methods: Twenty-three children (aged 6-17 years) with JCP-induced allergic rhinitis and sensitized to tomato (serum tomato fruit-specific IgE level >0.34 UA/ml) received JCP-based SCIT. Basophil activation by tomato and JCP extracts and serum-specific IgE and IgG 4 levels against these allergens were determined before and after 4 or 5 months of maintenance SCIT. Basophil activation was assessed by monitoring CD203c upregulation on flow cytometry. Results: JCP-based SCIT significantly reduced the basophil activation caused by tomato fruit (p = 0.03) and JCP (p < 0.001) extracts. JCP-specific IgG 4 levels markedly increased after SCIT (p < 0.001), whereas tomato fruit-specific IgG 4 levels did not. After SCIT, no significant changes were observed in specific IgE levels for tomato fruit (p = 0.11) or JCP (p = 0.19). Conclusions: Tomato fruit-specific basophil activation decreases after JCP-based SCIT, suggesting that it is efficacious in relieving and preventing the symptoms of PFAS in patients with JCP-induced allergic rhinitis.

Original languageEnglish
Pages (from-to)137-145
Number of pages9
JournalInternational Archives of Allergy and Immunology
Volume167
Issue number2
DOIs
Publication statusPublished - 02-09-2015

Fingerprint

Cryptomeria
Basophils
Lycopersicon esculentum
Pollen
Immunotherapy
Fruit
Immunoglobulin E
Food Hypersensitivity
Immunoglobulin G
Allergens
Seasonal Allergic Rhinitis
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Inuo, Chisato ; Kondo, Yasuto ; Tanaka, Kenichi ; Nakajima, Yoichi ; Nomura, Takayasu ; Ando, Hitoshi ; Suzuki, Satoko ; Tsuge, Ikuya ; Yoshikawa, Tetsushi ; Urisu, Atsuo. / Japanese cedar pollen-based subcutaneous immunotherapy decreases tomato fruit-specific basophil activation. In: International Archives of Allergy and Immunology. 2015 ; Vol. 167, No. 2. pp. 137-145.
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abstract = "Background: Some patients with Japanese cedar pollen (JCP)-induced allergic rhinitis develop pollen-food allergy syndrome (PFAS) as a reaction to tomato fruit. Pollen allergen-specific subcutaneous immunotherapy (SCIT) is reportedly beneficial for some associated food allergies; however, the reported changes in food allergen-specific immunoglobulin (Ig)E and IgG 4 levels are inconsistent. Here, we investigated immunologic reactivity to tomato fruit after JCP-based SCIT. Methods: Twenty-three children (aged 6-17 years) with JCP-induced allergic rhinitis and sensitized to tomato (serum tomato fruit-specific IgE level >0.34 UA/ml) received JCP-based SCIT. Basophil activation by tomato and JCP extracts and serum-specific IgE and IgG 4 levels against these allergens were determined before and after 4 or 5 months of maintenance SCIT. Basophil activation was assessed by monitoring CD203c upregulation on flow cytometry. Results: JCP-based SCIT significantly reduced the basophil activation caused by tomato fruit (p = 0.03) and JCP (p < 0.001) extracts. JCP-specific IgG 4 levels markedly increased after SCIT (p < 0.001), whereas tomato fruit-specific IgG 4 levels did not. After SCIT, no significant changes were observed in specific IgE levels for tomato fruit (p = 0.11) or JCP (p = 0.19). Conclusions: Tomato fruit-specific basophil activation decreases after JCP-based SCIT, suggesting that it is efficacious in relieving and preventing the symptoms of PFAS in patients with JCP-induced allergic rhinitis.",
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Japanese cedar pollen-based subcutaneous immunotherapy decreases tomato fruit-specific basophil activation. / Inuo, Chisato; Kondo, Yasuto; Tanaka, Kenichi; Nakajima, Yoichi; Nomura, Takayasu; Ando, Hitoshi; Suzuki, Satoko; Tsuge, Ikuya; Yoshikawa, Tetsushi; Urisu, Atsuo.

In: International Archives of Allergy and Immunology, Vol. 167, No. 2, 02.09.2015, p. 137-145.

Research output: Contribution to journalArticle

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T1 - Japanese cedar pollen-based subcutaneous immunotherapy decreases tomato fruit-specific basophil activation

AU - Inuo, Chisato

AU - Kondo, Yasuto

AU - Tanaka, Kenichi

AU - Nakajima, Yoichi

AU - Nomura, Takayasu

AU - Ando, Hitoshi

AU - Suzuki, Satoko

AU - Tsuge, Ikuya

AU - Yoshikawa, Tetsushi

AU - Urisu, Atsuo

PY - 2015/9/2

Y1 - 2015/9/2

N2 - Background: Some patients with Japanese cedar pollen (JCP)-induced allergic rhinitis develop pollen-food allergy syndrome (PFAS) as a reaction to tomato fruit. Pollen allergen-specific subcutaneous immunotherapy (SCIT) is reportedly beneficial for some associated food allergies; however, the reported changes in food allergen-specific immunoglobulin (Ig)E and IgG 4 levels are inconsistent. Here, we investigated immunologic reactivity to tomato fruit after JCP-based SCIT. Methods: Twenty-three children (aged 6-17 years) with JCP-induced allergic rhinitis and sensitized to tomato (serum tomato fruit-specific IgE level >0.34 UA/ml) received JCP-based SCIT. Basophil activation by tomato and JCP extracts and serum-specific IgE and IgG 4 levels against these allergens were determined before and after 4 or 5 months of maintenance SCIT. Basophil activation was assessed by monitoring CD203c upregulation on flow cytometry. Results: JCP-based SCIT significantly reduced the basophil activation caused by tomato fruit (p = 0.03) and JCP (p < 0.001) extracts. JCP-specific IgG 4 levels markedly increased after SCIT (p < 0.001), whereas tomato fruit-specific IgG 4 levels did not. After SCIT, no significant changes were observed in specific IgE levels for tomato fruit (p = 0.11) or JCP (p = 0.19). Conclusions: Tomato fruit-specific basophil activation decreases after JCP-based SCIT, suggesting that it is efficacious in relieving and preventing the symptoms of PFAS in patients with JCP-induced allergic rhinitis.

AB - Background: Some patients with Japanese cedar pollen (JCP)-induced allergic rhinitis develop pollen-food allergy syndrome (PFAS) as a reaction to tomato fruit. Pollen allergen-specific subcutaneous immunotherapy (SCIT) is reportedly beneficial for some associated food allergies; however, the reported changes in food allergen-specific immunoglobulin (Ig)E and IgG 4 levels are inconsistent. Here, we investigated immunologic reactivity to tomato fruit after JCP-based SCIT. Methods: Twenty-three children (aged 6-17 years) with JCP-induced allergic rhinitis and sensitized to tomato (serum tomato fruit-specific IgE level >0.34 UA/ml) received JCP-based SCIT. Basophil activation by tomato and JCP extracts and serum-specific IgE and IgG 4 levels against these allergens were determined before and after 4 or 5 months of maintenance SCIT. Basophil activation was assessed by monitoring CD203c upregulation on flow cytometry. Results: JCP-based SCIT significantly reduced the basophil activation caused by tomato fruit (p = 0.03) and JCP (p < 0.001) extracts. JCP-specific IgG 4 levels markedly increased after SCIT (p < 0.001), whereas tomato fruit-specific IgG 4 levels did not. After SCIT, no significant changes were observed in specific IgE levels for tomato fruit (p = 0.11) or JCP (p = 0.19). Conclusions: Tomato fruit-specific basophil activation decreases after JCP-based SCIT, suggesting that it is efficacious in relieving and preventing the symptoms of PFAS in patients with JCP-induced allergic rhinitis.

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