Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT

Hiroshi Matsuda, Miho Murata, Yohei Mukai, Kazuya Sako, Hidetoshi Ono, Hiroshi Toyama, Yoshitaka Inui, Yasuyuki Taki, Hideo Shimomura, Hiroshi Nagayama, Amane Tateno, Kenjiro Ono, Hidetomo Murakami, Atsushi Kono, Shigeki Hirano, Satoshi Kuwabara, Norihide Maikusa, Masayo Ogawa, Etsuko Imabayashi, Noriko Sato & 3 others Harumasa Takano, Jun Hatazawa, Ryosuke Takahashi

Research output: Contribution to journalArticle

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Abstract

Purpose: The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan. Methods: This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30–83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom. Results: The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30–39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70–79 age group. Conclusions: This study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database.

Original languageEnglish
Pages (from-to)1405-1416
Number of pages12
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume45
Issue number8
DOIs
Publication statusPublished - 01-07-2018

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Single-Photon Emission-Computed Tomography
Databases
Corpus Striatum
X Ray Computed Tomography
Age Groups
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
Calibration
Multicenter Studies
Japan
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Matsuda, Hiroshi ; Murata, Miho ; Mukai, Yohei ; Sako, Kazuya ; Ono, Hidetoshi ; Toyama, Hiroshi ; Inui, Yoshitaka ; Taki, Yasuyuki ; Shimomura, Hideo ; Nagayama, Hiroshi ; Tateno, Amane ; Ono, Kenjiro ; Murakami, Hidetomo ; Kono, Atsushi ; Hirano, Shigeki ; Kuwabara, Satoshi ; Maikusa, Norihide ; Ogawa, Masayo ; Imabayashi, Etsuko ; Sato, Noriko ; Takano, Harumasa ; Hatazawa, Jun ; Takahashi, Ryosuke. / Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT. In: European Journal of Nuclear Medicine and Molecular Imaging. 2018 ; Vol. 45, No. 8. pp. 1405-1416.
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abstract = "Purpose: The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan. Methods: This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30–83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom. Results: The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46{\%} lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3{\%} per decade. In the 30–39 age group, SBRs were 12.2{\%} higher in women than in men, but this increase declined with age and was absent in the 70–79 age group. Conclusions: This study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database.",
author = "Hiroshi Matsuda and Miho Murata and Yohei Mukai and Kazuya Sako and Hidetoshi Ono and Hiroshi Toyama and Yoshitaka Inui and Yasuyuki Taki and Hideo Shimomura and Hiroshi Nagayama and Amane Tateno and Kenjiro Ono and Hidetomo Murakami and Atsushi Kono and Shigeki Hirano and Satoshi Kuwabara and Norihide Maikusa and Masayo Ogawa and Etsuko Imabayashi and Noriko Sato and Harumasa Takano and Jun Hatazawa and Ryosuke Takahashi",
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Matsuda, H, Murata, M, Mukai, Y, Sako, K, Ono, H, Toyama, H, Inui, Y, Taki, Y, Shimomura, H, Nagayama, H, Tateno, A, Ono, K, Murakami, H, Kono, A, Hirano, S, Kuwabara, S, Maikusa, N, Ogawa, M, Imabayashi, E, Sato, N, Takano, H, Hatazawa, J & Takahashi, R 2018, 'Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT', European Journal of Nuclear Medicine and Molecular Imaging, vol. 45, no. 8, pp. 1405-1416. https://doi.org/10.1007/s00259-018-3976-5

Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT. / Matsuda, Hiroshi; Murata, Miho; Mukai, Yohei; Sako, Kazuya; Ono, Hidetoshi; Toyama, Hiroshi; Inui, Yoshitaka; Taki, Yasuyuki; Shimomura, Hideo; Nagayama, Hiroshi; Tateno, Amane; Ono, Kenjiro; Murakami, Hidetomo; Kono, Atsushi; Hirano, Shigeki; Kuwabara, Satoshi; Maikusa, Norihide; Ogawa, Masayo; Imabayashi, Etsuko; Sato, Noriko; Takano, Harumasa; Hatazawa, Jun; Takahashi, Ryosuke.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 45, No. 8, 01.07.2018, p. 1405-1416.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT

AU - Matsuda, Hiroshi

AU - Murata, Miho

AU - Mukai, Yohei

AU - Sako, Kazuya

AU - Ono, Hidetoshi

AU - Toyama, Hiroshi

AU - Inui, Yoshitaka

AU - Taki, Yasuyuki

AU - Shimomura, Hideo

AU - Nagayama, Hiroshi

AU - Tateno, Amane

AU - Ono, Kenjiro

AU - Murakami, Hidetomo

AU - Kono, Atsushi

AU - Hirano, Shigeki

AU - Kuwabara, Satoshi

AU - Maikusa, Norihide

AU - Ogawa, Masayo

AU - Imabayashi, Etsuko

AU - Sato, Noriko

AU - Takano, Harumasa

AU - Hatazawa, Jun

AU - Takahashi, Ryosuke

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Purpose: The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan. Methods: This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30–83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom. Results: The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30–39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70–79 age group. Conclusions: This study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database.

AB - Purpose: The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan. Methods: This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30–83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom. Results: The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30–39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70–79 age group. Conclusions: This study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database.

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