Joint biomarkers in idiopathic femoral head osteonecrosis: Comparison with hip osteoarthritis

Shinichi Kato, Harumoto Yamada, Nobuki Terada, Koichi Masuda, Mary Ellen Lenz, Mitsuhiro Morita, Yasuo Yoshihara, Osamu Henmi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective. To compare concentrations of joint biomarkers in synovial fluid (SF) between idiopathic osteonecrosis of the femoral head (ION) and osteoarthritis (OA) of the hip joint. Methods. Levels of the joint biomarkers cartilage oligomeric matrix protein (COMP), antigenic keratan sulfate (AgKS), and hyaluronan (HA) in SF samples from 21 cases of ION and their relationship to disease stage and history of steroid use were assessed and compared to the result of 29 cases of hip OA. Results. In both the ION and hip OA groups, levels of COMP and AgKS in SF showed a significant positive correlation. The ION group had significantly higher levels of AgKS in SF than the hip OA group. In the ION group, stage II patients had significantly higher SF levels of both COMP and AgKS than those in stage III patients. No difference in level of HA in hip joint SF was found between steroid and non-steroid treated ION patients or between the stage II and III subgroups. Conclusion. SF levels of COMP and AgKS may serve as useful joint biomarkers that reflect cartilage metabolism not only in hip OA but also in ION.

Original languageEnglish
Pages (from-to)1518-1523
Number of pages6
JournalJournal of Rheumatology
Volume32
Issue number8
Publication statusPublished - 01-08-2005

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Hip Osteoarthritis
Osteonecrosis
Synovial Fluid
Thigh
Keratan Sulfate
Cartilage Oligomeric Matrix Protein
Joints
Biomarkers
Hip Joint
Hyaluronic Acid
Steroids
Cartilage

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Kato, S., Yamada, H., Terada, N., Masuda, K., Lenz, M. E., Morita, M., ... Henmi, O. (2005). Joint biomarkers in idiopathic femoral head osteonecrosis: Comparison with hip osteoarthritis. Journal of Rheumatology, 32(8), 1518-1523.
Kato, Shinichi ; Yamada, Harumoto ; Terada, Nobuki ; Masuda, Koichi ; Lenz, Mary Ellen ; Morita, Mitsuhiro ; Yoshihara, Yasuo ; Henmi, Osamu. / Joint biomarkers in idiopathic femoral head osteonecrosis : Comparison with hip osteoarthritis. In: Journal of Rheumatology. 2005 ; Vol. 32, No. 8. pp. 1518-1523.
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Kato, S, Yamada, H, Terada, N, Masuda, K, Lenz, ME, Morita, M, Yoshihara, Y & Henmi, O 2005, 'Joint biomarkers in idiopathic femoral head osteonecrosis: Comparison with hip osteoarthritis', Journal of Rheumatology, vol. 32, no. 8, pp. 1518-1523.

Joint biomarkers in idiopathic femoral head osteonecrosis : Comparison with hip osteoarthritis. / Kato, Shinichi; Yamada, Harumoto; Terada, Nobuki; Masuda, Koichi; Lenz, Mary Ellen; Morita, Mitsuhiro; Yoshihara, Yasuo; Henmi, Osamu.

In: Journal of Rheumatology, Vol. 32, No. 8, 01.08.2005, p. 1518-1523.

Research output: Contribution to journalArticle

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AU - Kato, Shinichi

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AU - Terada, Nobuki

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AU - Lenz, Mary Ellen

AU - Morita, Mitsuhiro

AU - Yoshihara, Yasuo

AU - Henmi, Osamu

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N2 - Objective. To compare concentrations of joint biomarkers in synovial fluid (SF) between idiopathic osteonecrosis of the femoral head (ION) and osteoarthritis (OA) of the hip joint. Methods. Levels of the joint biomarkers cartilage oligomeric matrix protein (COMP), antigenic keratan sulfate (AgKS), and hyaluronan (HA) in SF samples from 21 cases of ION and their relationship to disease stage and history of steroid use were assessed and compared to the result of 29 cases of hip OA. Results. In both the ION and hip OA groups, levels of COMP and AgKS in SF showed a significant positive correlation. The ION group had significantly higher levels of AgKS in SF than the hip OA group. In the ION group, stage II patients had significantly higher SF levels of both COMP and AgKS than those in stage III patients. No difference in level of HA in hip joint SF was found between steroid and non-steroid treated ION patients or between the stage II and III subgroups. Conclusion. SF levels of COMP and AgKS may serve as useful joint biomarkers that reflect cartilage metabolism not only in hip OA but also in ION.

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Kato S, Yamada H, Terada N, Masuda K, Lenz ME, Morita M et al. Joint biomarkers in idiopathic femoral head osteonecrosis: Comparison with hip osteoarthritis. Journal of Rheumatology. 2005 Aug 1;32(8):1518-1523.