Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis

Akihiro Mouri, Mayu Ukai, Mizuki Uchida, Sho Hasegawa, Masayuki Taniguchi, Takahiro Ito, Hirotake Hida, Akira Yoshimi, Kiyofumi Yamada, Shohko Kunimoto, Norio Ozaki, Toshitaka Nabeshima, Yukihiro Noda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Adverse juvenile experiences, including physical abuse, often have negative health consequences later in life. We investigated the influence of social defeat stress exposure as juveniles on neuropsychological behaviors, and the causal role of glucocorticoids in abnormal behaviors and impairment of neurogenesis in mice exposed to the stress. The juvenile (24-day-old) and adult (70-day-old) male C57BL/6J mice were exposed to social defeat stress induced by an aggressive ICR mouse. Social defeat stress exposure as juveniles, even for 1 day, induced persistent social avoidance to the unfamiliar ICR mouse in the social interaction test, but that was not observed in mice exposed to the stress as adults. Social avoidance by the stress exposure as juveniles for 10 consecutive days was observed, when the target mouse was not only unfamiliar ICR but also another C57BL/J mouse, but not an absent or an anesthetized ICR mouse. The stress exposure did not induce anxiety- and depression-like behaviors in spontaneous locomotor activity, elevated plus-maze test, marble-burying test, forced swimming test, or sucrose preference test. Serum corticosterone levels increased immediately after the stress exposure. The hippocampal neurogenesis was suppressed 1 day and 4 weeks after the stress exposure. Administration of mifepristone, a glucocorticoid receptor antagonist, prior to each stress exposure, blocked the persistent social avoidance and suppression of neurogenesis. In conclusion, social avoidance induced by social defeat stress exposure as juveniles are more persistent than that as adults. These social avoidances are associated with suppression of hippocampal neurogenesis via glucocorticoid receptors.

Original languageEnglish
Pages (from-to)23-37
Number of pages15
JournalNeuropharmacology
Volume133
DOIs
Publication statusPublished - 01-05-2018

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Social Behavior
Neurogenesis
Inbred ICR Mouse
Glucocorticoid Receptors
Inbred C57BL Mouse
Mifepristone
Calcium Carbonate
Locomotion
Interpersonal Relations
Corticosterone
Glucocorticoids
Sucrose
Anxiety
Depression
Health
Serum

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Mouri, Akihiro ; Ukai, Mayu ; Uchida, Mizuki ; Hasegawa, Sho ; Taniguchi, Masayuki ; Ito, Takahiro ; Hida, Hirotake ; Yoshimi, Akira ; Yamada, Kiyofumi ; Kunimoto, Shohko ; Ozaki, Norio ; Nabeshima, Toshitaka ; Noda, Yukihiro. / Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis. In: Neuropharmacology. 2018 ; Vol. 133. pp. 23-37.
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abstract = "Adverse juvenile experiences, including physical abuse, often have negative health consequences later in life. We investigated the influence of social defeat stress exposure as juveniles on neuropsychological behaviors, and the causal role of glucocorticoids in abnormal behaviors and impairment of neurogenesis in mice exposed to the stress. The juvenile (24-day-old) and adult (70-day-old) male C57BL/6J mice were exposed to social defeat stress induced by an aggressive ICR mouse. Social defeat stress exposure as juveniles, even for 1 day, induced persistent social avoidance to the unfamiliar ICR mouse in the social interaction test, but that was not observed in mice exposed to the stress as adults. Social avoidance by the stress exposure as juveniles for 10 consecutive days was observed, when the target mouse was not only unfamiliar ICR but also another C57BL/J mouse, but not an absent or an anesthetized ICR mouse. The stress exposure did not induce anxiety- and depression-like behaviors in spontaneous locomotor activity, elevated plus-maze test, marble-burying test, forced swimming test, or sucrose preference test. Serum corticosterone levels increased immediately after the stress exposure. The hippocampal neurogenesis was suppressed 1 day and 4 weeks after the stress exposure. Administration of mifepristone, a glucocorticoid receptor antagonist, prior to each stress exposure, blocked the persistent social avoidance and suppression of neurogenesis. In conclusion, social avoidance induced by social defeat stress exposure as juveniles are more persistent than that as adults. These social avoidances are associated with suppression of hippocampal neurogenesis via glucocorticoid receptors.",
author = "Akihiro Mouri and Mayu Ukai and Mizuki Uchida and Sho Hasegawa and Masayuki Taniguchi and Takahiro Ito and Hirotake Hida and Akira Yoshimi and Kiyofumi Yamada and Shohko Kunimoto and Norio Ozaki and Toshitaka Nabeshima and Yukihiro Noda",
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Mouri, A, Ukai, M, Uchida, M, Hasegawa, S, Taniguchi, M, Ito, T, Hida, H, Yoshimi, A, Yamada, K, Kunimoto, S, Ozaki, N, Nabeshima, T & Noda, Y 2018, 'Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis', Neuropharmacology, vol. 133, pp. 23-37. https://doi.org/10.1016/j.neuropharm.2018.01.016

Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis. / Mouri, Akihiro; Ukai, Mayu; Uchida, Mizuki; Hasegawa, Sho; Taniguchi, Masayuki; Ito, Takahiro; Hida, Hirotake; Yoshimi, Akira; Yamada, Kiyofumi; Kunimoto, Shohko; Ozaki, Norio; Nabeshima, Toshitaka; Noda, Yukihiro.

In: Neuropharmacology, Vol. 133, 01.05.2018, p. 23-37.

Research output: Contribution to journalArticle

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T1 - Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis

AU - Mouri, Akihiro

AU - Ukai, Mayu

AU - Uchida, Mizuki

AU - Hasegawa, Sho

AU - Taniguchi, Masayuki

AU - Ito, Takahiro

AU - Hida, Hirotake

AU - Yoshimi, Akira

AU - Yamada, Kiyofumi

AU - Kunimoto, Shohko

AU - Ozaki, Norio

AU - Nabeshima, Toshitaka

AU - Noda, Yukihiro

PY - 2018/5/1

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N2 - Adverse juvenile experiences, including physical abuse, often have negative health consequences later in life. We investigated the influence of social defeat stress exposure as juveniles on neuropsychological behaviors, and the causal role of glucocorticoids in abnormal behaviors and impairment of neurogenesis in mice exposed to the stress. The juvenile (24-day-old) and adult (70-day-old) male C57BL/6J mice were exposed to social defeat stress induced by an aggressive ICR mouse. Social defeat stress exposure as juveniles, even for 1 day, induced persistent social avoidance to the unfamiliar ICR mouse in the social interaction test, but that was not observed in mice exposed to the stress as adults. Social avoidance by the stress exposure as juveniles for 10 consecutive days was observed, when the target mouse was not only unfamiliar ICR but also another C57BL/J mouse, but not an absent or an anesthetized ICR mouse. The stress exposure did not induce anxiety- and depression-like behaviors in spontaneous locomotor activity, elevated plus-maze test, marble-burying test, forced swimming test, or sucrose preference test. Serum corticosterone levels increased immediately after the stress exposure. The hippocampal neurogenesis was suppressed 1 day and 4 weeks after the stress exposure. Administration of mifepristone, a glucocorticoid receptor antagonist, prior to each stress exposure, blocked the persistent social avoidance and suppression of neurogenesis. In conclusion, social avoidance induced by social defeat stress exposure as juveniles are more persistent than that as adults. These social avoidances are associated with suppression of hippocampal neurogenesis via glucocorticoid receptors.

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