Kainic acid lesion-induced spatial memory deficits of rats

Lucian Hritcu, Toshitaka Nabeshima

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effects of lesioning the ventral tegmental area (VTA) or substantia nigra (SN) neurons by means of bilateral stereotaxic microinjections of kainic acid (KA) (0.4 mM) were investigated to clarify the role of the VTA and the SN neurons in learning and memory processes. The present study demonstrates that KA in the SN and the VTA lesioned rats significantly decreased spontaneous alternation in Y-maze task, working memory and reference memory in radial 8 arm-maze task, suggesting effects on spatial memory performance. Our findings provide further support for the role of the VTA and the SN neurons in processing and storage of information.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalCentral European Journal of Biology
Volume4
Issue number2
DOIs
Publication statusPublished - 01-06-2009

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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