Kainic acid lesion-induced spatial memory deficits of rats

Lucian Hritcu; Toshitaka Nabeshima

doi:10.2478/s11535-009-0001-9

Kainic acid lesion-induced spatial memory deficits of rats

Lucian Hritcu, Toshitaka Nabeshima

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The effects of lesioning the ventral tegmental area (VTA) or substantia nigra (SN) neurons by means of bilateral stereotaxic microinjections of kainic acid (KA) (0.4 mM) were investigated to clarify the role of the VTA and the SN neurons in learning and memory processes. The present study demonstrates that KA in the SN and the VTA lesioned rats significantly decreased spontaneous alternation in Y-maze task, working memory and reference memory in radial 8 arm-maze task, suggesting effects on spatial memory performance. Our findings provide further support for the role of the VTA and the SN neurons in processing and storage of information.

Original language	English
Pages (from-to)	179-185
Number of pages	7
Journal	Central European Journal of Biology
Volume	4
Issue number	2
DOIs	https://doi.org/10.2478/s11535-009-0001-9
Publication status	Published - 06-2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences

Access to Document

10.2478/s11535-009-0001-9

Cite this

@article{17c9d34c7a954f778648826b7f7a8a46,

title = "Kainic acid lesion-induced spatial memory deficits of rats",

abstract = "The effects of lesioning the ventral tegmental area (VTA) or substantia nigra (SN) neurons by means of bilateral stereotaxic microinjections of kainic acid (KA) (0.4 mM) were investigated to clarify the role of the VTA and the SN neurons in learning and memory processes. The present study demonstrates that KA in the SN and the VTA lesioned rats significantly decreased spontaneous alternation in Y-maze task, working memory and reference memory in radial 8 arm-maze task, suggesting effects on spatial memory performance. Our findings provide further support for the role of the VTA and the SN neurons in processing and storage of information.",

author = "Lucian Hritcu and Toshitaka Nabeshima",

note = "Funding Information: This research was supported by the National Council of Scientific Research and University Education (CNCSIS), Romania.",

year = "2009",

month = jun,

doi = "10.2478/s11535-009-0001-9",

language = "English",

volume = "4",

pages = "179--185",

journal = "Central European Journal of Biology",

issn = "1895-104X",

publisher = "Walter de Gruyter GmbH",

number = "2",

}

TY - JOUR

T1 - Kainic acid lesion-induced spatial memory deficits of rats

AU - Hritcu, Lucian

AU - Nabeshima, Toshitaka

N1 - Funding Information: This research was supported by the National Council of Scientific Research and University Education (CNCSIS), Romania.

PY - 2009/6

Y1 - 2009/6

N2 - The effects of lesioning the ventral tegmental area (VTA) or substantia nigra (SN) neurons by means of bilateral stereotaxic microinjections of kainic acid (KA) (0.4 mM) were investigated to clarify the role of the VTA and the SN neurons in learning and memory processes. The present study demonstrates that KA in the SN and the VTA lesioned rats significantly decreased spontaneous alternation in Y-maze task, working memory and reference memory in radial 8 arm-maze task, suggesting effects on spatial memory performance. Our findings provide further support for the role of the VTA and the SN neurons in processing and storage of information.

AB - The effects of lesioning the ventral tegmental area (VTA) or substantia nigra (SN) neurons by means of bilateral stereotaxic microinjections of kainic acid (KA) (0.4 mM) were investigated to clarify the role of the VTA and the SN neurons in learning and memory processes. The present study demonstrates that KA in the SN and the VTA lesioned rats significantly decreased spontaneous alternation in Y-maze task, working memory and reference memory in radial 8 arm-maze task, suggesting effects on spatial memory performance. Our findings provide further support for the role of the VTA and the SN neurons in processing and storage of information.

UR - http://www.scopus.com/inward/record.url?scp=65549118888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549118888&partnerID=8YFLogxK

U2 - 10.2478/s11535-009-0001-9

DO - 10.2478/s11535-009-0001-9

M3 - Article

AN - SCOPUS:65549118888

SN - 1895-104X

VL - 4

SP - 179

EP - 185

JO - Central European Journal of Biology

JF - Central European Journal of Biology

IS - 2

ER -

Kainic acid lesion-induced spatial memory deficits of rats

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this