Key regulators in neuronal polarity

Nariko Arimura, Kozo Kaibuchi

Research output: Contribution to journalShort surveypeer-review

119 Citations (Scopus)


Neurons are highly polarized cells, most of which develop a single axon and several dendrites. These two compartments acquire specific characteristics that enable neurons to transmit intercellular signals from several dendrites to an axon. A wealth of recent studies has shown that PI 3-kinase, Rho family GTPases, the Par complex, and cytoskeleton-related proteins participate in the initial events of neuronal polarization. Here, we review the role of polarity-regulating molecules and the potential mechanisms underlying the specification of an axon and dendrites.

Original languageEnglish
Pages (from-to)881-884
Number of pages4
Issue number6
Publication statusPublished - 22-12-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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