Key regulators in neuronal polarity

Nariko Arimura, Kozo Kaibuchi

Research output: Contribution to journalShort survey

112 Citations (Scopus)

Abstract

Neurons are highly polarized cells, most of which develop a single axon and several dendrites. These two compartments acquire specific characteristics that enable neurons to transmit intercellular signals from several dendrites to an axon. A wealth of recent studies has shown that PI 3-kinase, Rho family GTPases, the Par complex, and cytoskeleton-related proteins participate in the initial events of neuronal polarization. Here, we review the role of polarity-regulating molecules and the potential mechanisms underlying the specification of an axon and dendrites.

Original languageEnglish
Pages (from-to)881-884
Number of pages4
JournalNeuron
Volume48
Issue number6
DOIs
Publication statusPublished - 22-12-2005

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Key regulators in neuronal polarity'. Together they form a unique fingerprint.

  • Cite this